Yakakwirira Purity mishonga yepakati β-Nicotinamide Mononucleotide CAS:1094-61-7 Kufambisa kwakachengeteka kuve nechokwadi chekuregererwa kwetsika

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Uses
β-Nicotinamide mononucleotide (NMN) inoshandiswa kudzidza kusunga motifs mukati meRNA aptamers uye ribozyme activation process inosanganisira β-nicotinamide mononucleotide (β-NMN) -activated RNA fragments.NMN inonzi nucleotide inobva mu ribose uye nicotinamide.Niacinamide (nicotinamide,) inobva pavhitamini B3, inozivikanwawo se niacin.) Sezvinoita biochemical precursor yeNAD+, inogona kubatsira mukudzivirira pellagra.
β-Nicotinamide mononucleotide ndeyepakati mune biosynthesis ye nicotinamide adenine dinucleotide (NAD+).Nicotinamide phosphoribosyltransferase (Nampt) inokonzera condensation ye nicotinamide ne 5-phosphoribosyl-1-pyrophosphate kugadzira β-NMN, iyo inozoshandurwa kuva NAD + ne β-NMN adenyltransferase. NAD biosynthesis uye glucose-inosimudzira insulin secretion muNampt +/- mouse muenzaniso wechirwere chemagetsi, kuratidzira basa reNampt mu β cell function. Uyezve, pa 500 mg / kg / zuva, yakaratidzwa

Zvimwe

Nicotinamide mononucleotide ("NMN" uye" β- NMN ") inyucleotide yakabva mu ribose, Nicotinamide, Nicotinamide nucleoside uye nicotinic acid. Muvanhu, ma enzymes akawanda anoshandisa NMN kugadzira Nicotinamide adenine dinucleotide, NADH was In micleotide (NADH). kuti NMN yakanyura mumatumbo maduku mukati memaminitsi e10 mushure mekutonga kwemuromo uye yakashandurwa kuva Nicotinamide adenine dinucleotide (NAD +) kuburikidza neSlc12a8 transporter.

Nekuda kweNADH kuve cofactor yemitochondrial mukati maitiro, sirtuins, uye PARP, NMN yakadzidzwa seinogoneka neuroprotective uye anti-kuchembera mumiriri mumhando dzemhuka.Kana NAD + mazinga achiwedzera, inhibiting mitochondrial kuora kunogona kudzoreredza kuchembera padanho remasero, zvichiita kuti ive yakakurumbira muzvigadzirwa zvinorwisa kuchembera.Makambani ekuwedzera ezvekudya anoshingairira kusimudzira zvigadzirwa zveNMN, achiti ane mabhenefiti aya.Nekudaro, kusvika parizvino, hapasati pave nekudzidza kwevanhu kuratidza nemazvo maitiro ayo ekurwisa kuchembera.Ongororo yakaitwa neKeio University inoratidza kuti dhigirii rimwe chete rinosvika 500 mg rakachengeteka kuvarume.Muna 2021, kuyedzwa kwekiriniki kwakawana kuti NMN yakavandudza mhasuru ye insulin senitivity yevakadzi vane prediabetes, nepo imwe ongororo yekiriniki yakaona kuti yakavandudza aerobic kugona kwevatambi veamateur.

NMN iri nyore pasi pe extracellular degradation neCD38 enzymes, iyo inogona kudziviswa nemishonga yakadai seCD38-IN-78c.