I-CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

I-LVV-hemorphin-7 (LVV-h7) iyi-peptide ye-bioactive ebangelwa ukuwohloka kweketango le-hemoglobin β-globin.I-LVV-h7 iyi-agonist ethile ye-angiotensin IV receptor.Le receptor ingeyesigaba se-insulin-regulated aminopeptidase (IRAP) futhi inomsebenzi we-oxytocin.Lapha, sihlose ukuhlola: i) ukuthi i-LVV-h7 iyashintsha yini ukuziphatha kwezicubu ezigxilile kanye nokusabela kwenhliziyo nokucindezeleka, futhi ii) indlela eyisisekelo yemiphumela ye-LVV-h7 ihilela ukusebenza kwe-oxytocin (OT) receptor, okungenzeka umphumela wokuncipha komsebenzi we-IRAP we-proteolytic phakathi nesikhathi esengeziwe.Amagundane ama-Wistar amaduna amadala (270 -- 370 g) athole (ip) i-LVV-h7 (153 nmol/kg) noma inkampani yenethiwekhi (0.1 ml).Kusetshenziswe amaphrothokholi ahlukene: i) Ukuhlolwa kwe-Open Field (OP) kwemisebenzi yezemidlalo/yokuhlola;ii) Elevated Cross mazes (EPMs) zokuziphatha okufana nokukhathazeka;iii) Ukuhlolwa kokubhukuda okuphoqelekile (i-FST) kokuziphatha okufana nokucindezeleka kanye ne-iv) umjovo womoya wokusabela kwenhliziyo nemithambo yegazi ekuchayekeni kokucindezeleka okukhulu.I-Diazepam (2 mg/kg) ne-imipramine (15 mg/kg) isetshenziswe njengezilawuli ezinhle ze-EPM ne-FST, ngokulandelana.Abaphikisi be-OT receptor (OTr) i-atosiban (1 kanye ne-0.1 mg/kg) basetshenziselwe ukunquma ukubandakanyeka kwendlela ye-oxytocin.Sithole ukuthi i-LVV-h7: i) yenyusa inombolo yokungenela kanye nesikhathi esichithwa ku-maze ngezandla ezivulekile, okwakubonisa ukulwa nokukhathazeka;ii) Ukuvuselela imiphumela ye-antidepressant ekuhlolweni kwe-FS;iii) Ukwanda kokuhlola nokunyakaza;iv) ayizange iguqule izimpendulo zenhliziyo ne-neuroendocrine ekucindezelekeni okukhulu.Ukwengeza, ukuvivinya umzimba okwandisiwe kanye nemiphumela ye-LVV-h7 eyenziwe ye-antidepressant ibuyiselwe ngabaphikisi be-OTr.Siphetha ngokuthi i-LVV-h7 ishintsha ukuziphatha okuboniswe ngokwengxenye yi-oxytocin receptor.