I-Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

incazelo emfushane:

INOMBOLO YE-CAS:170713-75-4

Igama:I-Nociceptin

ukuminyana :1.47±0.1 g/cm3(Kubikezelwe)

pka:3.19±0.10(Okubikezelwe)

izinga lokushisa lokugcina.:−20°C

Ifomula yekhemikhali:I-C79H129N27O22

ifomu:impushana

I-Molar mass:1809.04

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Ukusetshenziswa

I-Nonoreceptor/orphenkephalin FQ (N/OFQ) iyi-17-amino acid neuropeptide eyi-endogenous ligand ye-nonoreceptor (ORL-1).I-nociceptive peptide, njengesidakamizwa esiphumelelayo se-antianalgesic, ingamelana ngokuphumelelayo nomphumela wama-painkillers.Ukusebenza kwayo kuye kwaxhunyaniswa nemisebenzi yobuchopho njengokubona ubuhlungu nokufunda ukwesaba.

Ikhodi yofuzo ye-prepronociceptin itholakala ku-Ch8p21 yomuntu.Ama-peptide azwela ubuhlungu atholakala kumaprotheni e-peptide azwelayo e-propain, kanye namanye ama-peptide amabili, i-nocistatin ne-NocII, womabili avimbela ukusebenza kwe-N/OFQ receptor.I-Nociceptin yayiyisibonelo sokuqala se-pharmacology ehlanekezelwe;I-NOP receptor yatholwa ngaphambi kokutholwa kwama-endogenous ligands ngamaqembu amabili ahlukene ngo-1995.

Ezifundweni zezilwane, indlela yokwamukela i-N/OFQ-NOP iphinde yatholakala idlala izindima ezinhle nezingezinhle ekufundeni nasekukhumbuleni.Isibonelo, ukuphazamiseka kule ndlela kuye kwaxhunyaniswa nezinguquko ekufundeni kokwesaba ezinkingeni zobuchopho ezifana ne-post-traumatic stress disorder (PTSD).Ngakho-ke, izindlela ze-receptor zigcina izimpendulo ze-homeostasis zokwesaba nezimo ezicindezelayo.I-Nociceptor nayo ingadlala indima yokuvimbela ekusebenzeni kwenkumbulo, njengoba ezinye izifundo zibonise ukuthi ziphazamisa ukufunda kwendawo ku-vivo ngenkathi kuvimbela ukuthuthukiswa kwesikhathi eside kanye nokudluliselwa kwe-synaptic in vitro.