CAS: 152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

LVV-hemorphin-7 (LVV-h7) peptide ne mai bioactive wanda ya haifar da lalacewar sarkar haemoglobin β-globin.LVV-h7 shine takamaiman agonist don mai karɓar angiotensin IV.Wannan mai karɓa yana cikin rukunin aminopeptidase mai sarrafa insulin (IRAP) kuma yana da aikin oxytocin.Anan, muna nufin kimantawa: i) ko LVV-h7 ya canza dabi'ar kyamarorin da aka tattara da kuma amsawar zuciya ga danniya, da ii) tsarin tushen tasirin LVV-h7 ya haɗa da kunna mai karɓar oxytocin (OT), wanda zai iya zama sakamakon rage ayyukan IRAP proteolytic a lokacin kari.Berayen Wistar na manya (270 -- 370 g) sun karɓi (ip) LVV-h7 (153 nmol/kg) ko mai ɗauka (0.1 ml).An yi amfani da ka'idoji daban-daban: i) Buɗe filin (OP) gwaji don ayyukan wasanni / bincike;ii) Ƙwararren mazes (EPMs) don halin damuwa;iii) Gwajin tilasta yin iyo (FST) gwajin hali-kamar baƙin ciki da iv) allurar iska don amsawar bugun jini zuwa ga tsananin damuwa.Diazepam (2 mg/kg) da imipramine (15 mg/kg) an yi amfani da su azaman ingantattun sarrafawa ga EPM da FST, bi da bi.OT receptor (OTr) antagonists atesiban (1 da 0.1 mg / kg) an yi amfani da su don ƙayyade shigar da hanyar oxytocin.Mun gano cewa LVV-h7: i) ƙara yawan adadin shigarwar da lokacin da aka kashe a cikin maze tare da bude hannu, wanda ya nuna damuwa;ii) Ƙarfafa tasirin antidepressant a cikin gwaje-gwajen FS;iii) Ƙara bincike da motsi;iv) bai canza martani na zuciya da jijiyoyin jini da neuroendocrine ga matsanancin damuwa ba.Bugu da ƙari, ƙara yawan motsa jiki da LVV-h7 ya haifar da tasirin antidepressant an dawo da su ta hanyar masu adawa da OTr.Mun kammala cewa LVV-h7 yana daidaita halayen da aka nuna a sashi ta hanyar mai karɓar oxytocin.