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CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7 Setšoantšo se Featured
  • CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7
  • CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7
  • CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7
  • CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

tlhaloso e khuts'oane:


  • NOMORO YA CAS:152685-85-3
  • Lebitso:HEMORFIN-7
  • Foromo ea lik'hemik'hale:C49H64N12O11
  • density :1.47±0.1 g/cm3(E boletsoeng esale pele)
  • pka:3.50±0.10(E boletsoeng esale pele)
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    Tšebeliso

    LVV-hemorphin-7 (LVV-h7) ke peptide ea bioactive e bakoang ke ho senyeha ha ketane ea hemoglobin β-globin.LVV-h7 ke agonist e khethehileng bakeng sa li-receptor tsa angiotensin IV.Receptor ena ke ea sehlopha sa insulin-regulated aminopeptidase (IRAP) mme e na le ts'ebetso ea oxytocin.Mona, re ikemiselitse ho hlahloba: i) hore na LVV-h7 e fetola boitšoaro ba lisele tse tsepamisitsoeng le karabelo ea pelo khatellong ea maikutlo, le ii) mokhoa o ka sehloohong oa liphello tsa LVV-h7 o kenyelletsa ts'ebetsong ea oxytocin (OT) receptor, e ka 'nang ea e-ba eona sephetho sa ts'ebetso e fokotsehileng ea IRAP ea proteolytic nakong ea nako e eketsehileng.Litoeba tse tona tsa Wistar tse holileng (270 -- 370 g) li amohetse (ip) LVV-h7 (153 nmol/kg) kapa mojari (0.1 ml).Ho ile ha sebelisoa li-protocol tse fapaneng: i) Teko ea Open Field (OP) bakeng sa mesebetsi ea lipapali / ea ho hlahloba;ii) Elevated Cross mazes (EPMs) bakeng sa boitšoaro bo kang ba ho tšoenyeha;iii) Teko e qobelloang ea ho sesa (FST) bakeng sa boitšoaro bo kang ba ho tepella maikutlong le iv) ente ea moea bakeng sa karabo ea pelo le methapo ea pelo ho pepesehela khatello ea kelello e matla.Diazepam (2 mg / kg) le imipramine (15 mg / kg) li ne li sebelisoa e le taolo e ntle bakeng sa EPM le FST, ka ho latellana.Bahanyetsi ba OT receptor (OTr) ba atosiban (1 le 0.1 mg / kg) ba ne ba sebelisetsoa ho fumana karolo ea tsela ea oxytocin.Re fumane hore LVV-h7: i) e ekelitse palo ea ho kena le nako e sebelisitsoeng ka har'a maze ka matsoho a bulehileng, e leng se bontšang khahlanong le ho tšoenyeha;ii) Ho susumetsa litlamorao tse thibelang ho imeloa kelellong litekong tsa FS;iii) Keketseho ea lipatlisiso le motsamao;iv) ha ea ka ea fetola likarabo tsa pelo le methapo ea kutlo ho khatello e matla.Ntle le moo, boikoetliso bo eketsehileng le litlamorao tse bakiloeng ke LVV-h7 li ile tsa khutlisoa ke bahanyetsi ba OTr.Re etsa qeto ea hore LVV-h7 e fetola boitšoaro bo bontšitsoeng ka karolo ea oxytocin receptor.

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