CAS:152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

LVV-hemorphin-7 (LVV-h7) ndi bioactive peptide chifukwa cha kuwonongeka kwa hemoglobin β-globin chain.LVV-h7 ndi agonist yapadera ya angiotensin IV receptor.Cholandilira ichi ndi cha kalasi ya insulin-regulated aminopeptidase (IRAP) ndipo imakhala ndi ntchito ya oxytocin.Pano, tikufuna kuyesa: i) ngati LVV-h7 imasintha khalidwe la minyewa yokhazikika komanso kuyankha kwamtima kupsinjika, ndipo ii) njira yayikulu ya LVV-h7 zotsatira imaphatikizapo kuyambitsa kwa oxytocin (OT) receptor, yomwe ingakhale zotsatira za kuchepa kwa IRAP proteolytic ntchito panthawi yowonjezera.Makoswe akuluakulu amphongo a Wistar (270 -- 370 g) analandira (ip) LVV-h7 (153 nmol/kg) kapena chonyamulira (0.1 ml).Ma protocol osiyanasiyana anagwiritsidwa ntchito: i) Kuyesa kwa Open Field (OP) pazochitika zamasewera / kufufuza;ii) Elevated Cross mazes (EPMs) zamakhalidwe ngati nkhawa;iii) Mayeso okakamiza osambira (FST) a khalidwe lofanana ndi kuvutika maganizo ndi iv) jakisoni wa mpweya wa mtima wamtima pokhudzana ndi kupsinjika kwakukulu.Diazepam (2 mg / kg) ndi imipramine (15 mg / kg) adagwiritsidwa ntchito ngati zowongolera zabwino za EPM ndi FST, motsatana.Otsutsa a OT receptor (OTr) atosiban (1 ndi 0.1 mg / kg) adagwiritsidwa ntchito kuti adziwe kukhudzidwa kwa njira ya oxytocin.Tinapeza kuti LVV-h7: i) inawonjezera chiwerengero cha zolembera ndi nthawi yogwiritsidwa ntchito mumpikisano ndi manja otseguka, zomwe zimasonyeza kudana ndi nkhawa;ii) Kulimbikitsa zotsatira za antidepressant pamayeso a FS;iii) Kuwonjezeka kwa kufufuza ndi kuyenda;iv) sizinasinthe mayankho amtima ndi neuroendocrine pakupsinjika kwakukulu.Kuonjezera apo, kuchita masewera olimbitsa thupi ndi LVV-h7 kumapangitsa kuti anthu azivutika maganizo anabwezeretsedwa ndi otsutsa a OTr.Timatsimikiza kuti LVV-h7 imasintha khalidwe lomwe likuwonetsedwa mwa gawo ndi oxytocin receptor.