I-Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507

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INOMBOLO YECASS:804475-66-9

Igama:Tesamorelin

Ifomula yemichiza:I-C221H366N72O67S

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Ukusetyenziswa

I-Tesamorelin (INN) (igama lokurhweba i-Egrifta SV) yindlela yokwenziwa ye-hormone yokukhula ekhupha i-hormone (GHRH) yonyango lwe-lipodystrophy ehambelana ne-HIV kwaye yavunywa ekuqaleni kwi-2010. Iveliswa kwaye iphuhliswe yi-Theratechnologies, Inc. Canada.Ichiza yi-peptide yokwenziwa eyenziwe ngayo yonke i-44 amino acids ye-GHRH yabantu kunye nokongezwa kweqela le-trans-3-hexenoic acid.

Indlela yokwenza
I-Tesamorelin yi-N-terminus eguqulelwe i-compound esekelwe kwi-44 yokulandelelana kwe-amino acid ye-GHRH yomntu.Le fomu yokwenziwa elungisiweyo isebenza ngakumbi kwaye izinzile kuneepeptide zendalo.Ikwaxhathisa ngakumbi ukucandwa yidipeptide aminopeptidase kuneGHRH yabantu.Ivuselela i-GH engapheliyo kunye nokukhululwa kunye nokwandisa amanqanaba e-insulin-like ukukhula factor (IGF-1).I-GH ekhutshiweyo emva koko ibophelela kwi-receptors ekhoyo kumalungu ahlukeneyo omzimba kwaye ilawula ukubunjwa komzimba.Lo mmiselo ikakhulu ngenxa yokudibanisa i-anabolic kunye neendlela ze-lipolysis.Nangona kunjalo, eyona ndlela iphambili ekufunyenwe ngayo i-tesamoline ukunciphisa ubunzima bomzimba kukunciphisa amanqanaba e-triglyceride emva kwe-lipolysis.