I-Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507

I-Tesamorelin (INN) (igama lokuhweba i-Egrifta SV) iwuhlobo lokwenziwa lwe-hormone yokukhula ekhulula i-hormone (GHRH) yokwelapha i-lipodystrophy ehambisana ne-HIV futhi yavunywa ekuqaleni ngo-2010. Ikhiqizwa futhi yathuthukiswa yi-Theratechnologies, Inc. Canada.Umuthi uyi-peptide yokwenziwa eyakhiwe ngawo wonke ama-amino acid angama-44 we-GHRH yomuntu kanye nokwengezwa kweqembu le-trans-3-hexenoic acid.

Indlela yokwenza
I-Tesamorelin iyinhlanganisela eguquliwe ye-N-terminus esekelwe ukulandelana kwe-amino acid ye-44 ye-GHRH yomuntu.Leli fomu lokwenziwa eliguquliwe lisebenza kangcono futhi lizinzile kunama-peptide emvelo.Iphinde imelane kakhulu nokuqhekeka nge-dipeptide aminopeptidase kune-GHRH yomuntu.Ivuselela ukuhlanganiswa kwe-GH endo native kanye nokukhululwa futhi ikhulise amazinga we-insulin-like growth factor (IGF-1).I-GH ekhishwe bese ibophezela kuma-receptors akhona ezingxenyeni ezihlukahlukene zomzimba futhi ilawula ukwakheka komzimba.Lo mthethonqubo ikakhulukazi ngenxa yokuhlanganiswa kwe-anabolic kanye nezindlela ze-lipolysis.Kodwa-ke, indlela eyinhloko okutholwe ngayo i-tesamoline yehlisa isisindo samafutha emzimbeni ukwehla kwamazinga e-triglyceride ngemuva kwe-lipolysis.