ILarazotide acetate CAS 881851-50-9
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Uphawu:
| igama eliqhelekileyo | ILarazotide Acetate | Igama lesiNgesi | Larazotide acetate |
|---|---|---|---|
| Inombolo yeCAS | 881851-50-9 | ubunzima bemolekyuli | 785.88500 |
| ifomula yemolekyuli | C34H59N9O12 |
|---|
| ubunzima obuchanekileyo | 785.42800 |
|---|---|
| PSA | 360.55000 |
| LogP | 3.73650 |
Ukusetyenziswa:
ILarazotide acetate lichiza lokulawula intestinal tight-junction, elalifudula libizwa ngokuba yi-Innovate Biopharmaceuticals phambi kokudityaniswa, elivavanywa ngoku kwizigulane zabantu abadala abanesifo se-celiac kwisigaba sesi-III solingo lwezonyango.Le peptide yetsheyini enye ithathwe kwi-zonulin yomntu, imodyuli eyaziwayo ye-tight junction permeability eye yaphakamisa ukubonakaliswa kwezicubu zamathumbu kwizigulana ezinesifo se-celiac.I-LA ikwabelana ngokufana kwesakhiwo kwi-Vibrio cholerae zonula occludens toxin (i-Zot), eyi-enterotoxin ephazamisa i-intercellular tight junction structure ngokusebenzisa i-actin polymerization kunye nokuguqulwa kwe-cytoskeletal okubangelwa ukunyuka kwamathumbu emathunjini ngokusebenzisa ukubonakaliswa kwe-intracellular.Nangona i-LA ibonise isithembiso kwizilingo zeklinikhi kwizigulane ezinesifo se-celiac, izifundo zamva nje zisebenzisa imizekelo eyahlukeneyo yokulimala kwezilwanyana zibonisa ukusetyenziswa okunokwenzeka kwe-LA kwezinye izifo ngenxa yokukwazi ukulawula ukudibanisa okuqinileyo.Olu phononongo luncinci lujolise ekuboneleleni ngomthombo oneenkcukacha zangoku kule octapeptide.
