IGlucagon CAS: 16941-32-5 IGlucagon (1-29) IHCl yomntu IGLUCAGON 1-37

IGlucagon CAS: 16941-32-5 Glucagon(1-29) Human HCl GLUCAGON 1-37 Featured Image

inkcazelo emfutshane:

INOMBOLO YECASS:16941-32-5

Igama:IGlucagon

Ifomula yemichiza:I-C153H225N43O49S

Ubuninzi :1.53±0.1 g/cm3(Kuxelwe kwangaphambili)

ixesha lokugcina.:Gcina kwindawo emnyama, ivalwe kwindawo eyomileyo, 2-8°C

ifom:umgubo

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Ukusetyenziswa

IGlucagon, ekwabizwa ngokuba yi-hyperglycemin kunye neglucagon, yihomoni ye-polypeptide yetsheyini ethe ngqo ekhutshwe ziiseli ze-α ze-pancreatic islet, equlethe ama-29 amino acid.Ifomula yayo ye-molecular kunye nobunzima be-molecular weight C153H225N43O49S = 3482.8.Le hormone yenziwe kwilizwe lam.Umgubo omhlophe wekristale ococekileyo kubushushu begumbi, awunavumba, awunancasa.Ayinyibiliki emanzini nakwizinyibilikisi ezininzi zezinto eziphilayo, zinyibilika kwi-asidi edibeneyo kunye ne-lyete ye-lye.Uninzi lwamalungiselelo enziwe nge-hydrochloride yayo, enyibilikayo emanzini.Ngoku iyaziwa ukuba iglucagon kufuneka igcine ingqibelelo yayo yeemolekyuli ukuze yenze umsebenzi wayo womzimba.Isakhiwo se-hyperglycemic sinokuhambelana nabantu kunye nezilwanyana ezincelisayo (imivundla, iinkomo, iihagu, iigundane, njl.), kodwa zihluke kancinci kwiintaka.I-hormone ebalulekileyo yokugcina iswekile yegazi eqhelekileyo.Umsebenzi wayo oyintloko kukuvula i-phosphorylase kwi-myocardium, ukukhuthaza ukubola kwe-glycogen kunye nemiphumo efana ne-catecholamin.Ke ngoko, inefuthe elinamandla lentliziyo entliziyweni, inyusa izinga lokubetha kwentliziyo, i-myocardial contractility kunye ne-coronary blood flow.I-Cardioenhancement ayihambisani nokunyuka kwe-cardiac excitability, kodwa kwandisa i-calcium ions kwi-cardiomyocytes kwaye ingenza i-adenosine cyclase isebenze kwi-membrane yeseli yesibindi kwi-Chemicalbook, ukukhuthaza ukuhlanganiswa kwe-cyclic adenosine phosphate kwiiseli.IGlucagon kuxelwe ukuba iyasebenza kwezinye iimeko zokusilela kwentliziyo.Ukongeza, amanqanaba eplasma nawo anda ukuya kumaqondo ahlukeneyo kwisifo seswekile, isifo sesibindi, isifo sezintso, ithumba leglucagon kunye noxinzelelo.I-Glucagon inemisebenzi emine ye-physiological yokukhuthaza i-glycogenolysis yesibindi, i-glycogenogenesis yesibindi, i-lipolysis kunye nokwakheka komzimba we-ketone.Inokukhuthaza ukufunyanwa kwama-amino acids kwiiseli zesibindi, ukukhawulezisa inkqubo yokuchithwa kwe-amino acids esibindi, ukunciphisa ukuxinwa kwama-amino acids kwi-plasma, ukunciphisa i-protein synthesis kunye nokukhuthaza isibindi se-glycogenogenesis.Ukongeza, inokuphinda isebenze amandla e-lipase yeeseli zesibindi zokugcina i-lipid, yandise ukukhululwa kwe-fatty acids yamahhala, ikhawulezise inkqubo ye-lipoic acid oxidation yeeseli zesibindi, kunye nokwandisa ukuveliswa kwesibindi se-glycoconeogenesis kunye nemizimba ye-ketone.Kwangaxeshanye, iglucagon inokuthintela uxinzelelo kunye ne-peristalsis yesisu, amathumbu amancinci kunye nekholoni, ukunciphisa uxinzelelo lwe-gallbladder, inqanda i-pancreatic exocrine, kwaye inqanda ukufunxwa kwamanzi kunye netyuwa nge-mucosa yamathumbu.Iidosi ezinkulu zeglucagon zinokonyusa uxinzelelo lwe-cAMP kwiiseli ze-myocardial, ukonyusa izinga lokubetha kwentliziyo kunye nokuphucula ukunyibilika kwe-myocardial.