Larazotide acetate CAS 881851-50-9
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Siffa:
| gama gari | Larazotide acetate | Sunan Ingilishi | Larazotide acetate |
|---|---|---|---|
| Lambar CAS | 881851-50-9 | nauyin kwayoyin halitta | 785.88500 |
| tsarin kwayoyin halitta | C34H59N9O12 |
|---|
| m taro | 785.42800 |
|---|---|
| PSA | 360.55000 |
| LogP | 3.73650 |
Amfani:
Larazotide acetate magani ne na intestinal tight-junction regulator, wanda aka sani da Innovate Biopharmaceuticals kafin haɗuwa, wanda a halin yanzu ana gwada shi a cikin manya marasa lafiya da cutar celiac a cikin gwaji na asibiti na III.Wannan peptide mai sarkar guda ɗaya an samo shi ne daga zonulin ɗan adam, sanannen mai daidaita junction permeability wanda ya ɗaga bayyanar nama na hanji a cikin marasa lafiya da cutar celiac.LA kuma yana raba kamanceceniya na tsari da Vibrio cholerae zonula occludens toxin (Zot), wanda shine enterotoxin wanda ke rushe tsarin haɗin gwiwar salula ta hanyar actin polymerization da gyare-gyaren cytoskeletal wanda ke haifar da haɓakar hanji ta hanyar siginar intracellular.Kodayake LA ya nuna alƙawarin a cikin gwaje-gwaje na asibiti ga marasa lafiya da cutar celiac, binciken da aka yi kwanan nan ta yin amfani da nau'o'in raunin dabba na dabba yana nuna yiwuwar amfani da LA don wasu cututtuka saboda ikonsa na daidaita matakan haɗin gwiwa.Wannan ƙaramin bita yana nufin samar da cikakken tushen bayanai na yanzu akan wannan octapeptide.
