Tom ntej: Larazotide Acetate CAS 881851-50-9
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Yam ntxwv:
| hom npe | Larazotide Acetate | English npe | Larazotide acetate hmoov |
|---|---|---|---|
| CAS nr | 881851-50-9 | molecular hnyav | 785.88500 ib |
| molecular formula | C34H59N9O12 |
|---|
| raug pawg | 785.42800 ib |
|---|---|
| PSA | 360.55 000 Nws |
| LogP | 3.73650 ib |
Kev siv:
Larazotide acetate yog ib qho tshuaj siv tshuaj tua kab mob hauv plab hnyuv, yav tas los hu ua Innovate Biopharmaceuticals ua ntej kev sib koom ua ke, uas tam sim no tau sim rau cov neeg laus uas muaj kab mob celiac hauv theem III kev sim tshuaj.Qhov no ib leeg-chain peptide yog muab los ntawm tib neeg zonulin, ib tug paub modulator ntawm nruj hlws ris permeability uas tau elevated plab hnyuv cov ntaub so ntswg qhia nyob rau hauv cov neeg mob uas muaj kab mob celiac.LA kuj qhia txog cov qauv zoo sib xws rau Vibrio cholerae zonula occludens toxin (Zot), uas yog enterotoxin uas cuam tshuam cov qauv sib txuas ntawm cov cellular nruj nreem los ntawm actin polymerization thiab cytoskeletal hloov kho uas ua rau muaj zog plab hnyuv permeability los ntawm intracellular signaling.Txawm hais tias LA tau pom cov lus cog tseg hauv kev sim tshuaj rau cov neeg mob uas muaj kab mob celiac, cov kev tshawb fawb tsis ntev los no siv ntau yam tsiaj raug mob qauv qhia tias muaj peev xwm siv rau LA rau lwm yam kab mob vim tias nws muaj peev xwm tswj tau nruj junctions.Qhov kev tshuaj xyuas me me no yog tsim los muab cov ncauj lus ntxaws ntxaws ntawm cov ntaub ntawv tam sim no ntawm octapeptide no.
