Larazotide acetate CAS 881851-50-9
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uiga:
| igoa masani | Larazotide Acetate | igoa faaperetania | Larazotide acetate |
|---|---|---|---|
| Numera CAS | 881851-50-9 | mamafa mole | 785.88500 |
| fua mole mole | C34H59N9O12 |
|---|
| mamafa sa'o | 785.42800 |
|---|---|
| PSA | 360.55000 |
| LogP | 3.73650 |
Fa'aoga:
Larazotide acetate o se intestinal tight-junction regulator drug, na taʻua muamua o Innovate Biopharmaceuticals aʻo leʻi tuʻufaʻatasia, lea o loʻo faʻataʻitaʻiina nei i tagata matutua maʻi maʻi celiac i le vaega III faʻataʻitaʻiga faʻataʻitaʻiga.O lenei peptide filifili tasi e maua mai i le zonulin a le tagata, o se faʻaogaina o le faʻaogaina o fesoʻotaʻiga vavalalata e faʻateleina ai le faʻaaliga o le intestinal i tagata mamaʻi e maua i le maʻi celiac.O loʻo faʻasoa foʻi e LA le faʻatulagaga tutusa ma le Vibrio cholerae zonula occludens toxin (Zot), o se enterotoxin e faʻalavelaveina le faʻaogaina o fesoʻotaʻiga vavalalata intercellular e ala i le actin polymerization ma le cytoskeletal modifications e mafua ai le faʻateleina o le intestinal permeability e ala i le faʻailoga intracellular.E ui lava na faʻaalia e LA le folafolaga i faʻataʻitaʻiga faʻapitoa mo tagata mamaʻi e maua i le maʻi celiac, o suʻesuʻega talu ai nei e faʻaogaina ai manuʻa manu eseese faʻataʻitaʻiga o loʻo faʻaalia ai se faʻaoga talafeagai mo LA mo isi faʻamaʻi ona o lona gafatia e faʻatonutonuina vaʻavaʻa.O lenei su'esu'ega laiti e fa'amoemoe e tu'uina atu se fa'amatalaga auiliili o fa'amatalaga lata mai i lenei octapeptide.
