I-Larazotide acetate CAS 881851-50-9

incazelo emfushane:

Igama elijwayelekile:I-Larazotide Acetate

Inombolo ye-CAS:881851-50-9

Ifomula ye-molecular:I-C34H59N9O12

Isisindo samangqamuzana:785.88536

Iphoyinti lokuncibilika:>231°C (dec.)

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Isici:

igama elivamile	I-Larazotide Acetate	Igama lesiNgisi	I-Larazotide acetate
Inombolo ye-CAS	881851-50-9	isisindo samangqamuzana	785.88500

ifomula yamangqamuzana	C34H59N9O12

isisindo esinembile	785.42800
I-PSA	360.55000
I-LogP	3.73650

Ukusetshenziswa:

I-Larazotide acetate isidakamizwa esilawula ukuhlangana kwe-tight-junction emathunjini, ngaphambili esaziwa ngokuthi i-Innovate Biopharmaceuticals ngaphambi kokuhlanganiswa, okwamanje esihlolwayo ezigulini ezikhulile ezinesifo se-celiac esivivinyweni somtholampilo sesigaba sesi-III.Le peptide yochungechunge olulodwa isuselwa ku-zonulin yomuntu, imoduli eyaziwayo yokuqina kwe-tight junction eye yaphakamisa ukubonakaliswa kwezicubu zamathumbu ezigulini ezinesifo se-celiac.I-LA iphinde ihlanganyele ukufana kwesakhiwo ne-Vibrio cholerae zonula occludens toxin (Zot), okuyi-enterotoxin ephazamisa ukwakheka kwe-intercellular tight junction ngokusebenzisa i-actin polymerization kanye nokuguqulwa kwe-cytoskeletal okuholela ekwandeni kokungena kwamathumbu ngokusebenzisa ukusayina kwe-intracellular.Nakuba i-LA ibonise isithembiso esivivinyweni somtholampilo ezigulini ezinesifo se-celiac, izifundo zamuva zisebenzisa izinhlobo ezihlukahlukene zokulimala kwezilwane zibonisa ukusetshenziswa okungenzeka kwe-LA kwezinye izifo ngenxa yekhono layo lokulawula ukuhlangana okuqinile.Lokhu kubuyekezwa okuncane kuhlose ukuhlinzeka ngomthombo onemininingwane wolwazi lwamanje ngale octapeptide.