I-Anti-Aging Hexapeptide-11 CAS 161258-30-6 Yehlisa ukubukeka kwemibimbi

I-Hexapeptide-11 Anti-aging CAS 161258-30-6 Yehlisa ukubukeka kwemibimbi Isithombe esifakiwe

incazelo emfushane:

Igama elijwayelekile:I-Hexapeptide-11

Inombolo ye-CAS:161258-30-6

Ifomula ye-molecular:I-C36H48N6O7

Isisindo samangqamuzana:676.8

Iphakheji:Ibhodlela,Isikhwama,Ikhathoni,Isigubhu

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Isici:

Igama elivamile	I-Hexapeptide-11	Igama lesiNgisi	I-Hexapeptide-11
Inombolo ye-CAS	161258-30-6

Ifomula yamangqamuzana	C36H48N6O7
Isisindo samangqamuzana	676.80200
Isisindo esinembile	676.35800
I-PSA	201.71000
I-LogP	4.09300

Ukusetshenziswa:

IHexapeptide-11 iyimoduli yenoveli yenethiwekhi ye-proteostasis kuma-diploid fibroblasts womuntu.

I-Hexapeptide-11 yehlisa ukubukeka kwemigqa emihle nemibimbi, okwenza lokhu kube isengezo esihle kakhulu kuzo zonke izinhlobo zokunakekelwa kwesikhumba nemikhiqizo elwa nokuguga.Inesethi eyingqayizivele yama-amino acid asiza ukuphatha amazinga e-collagen futhi akhulise ukunwebeka esikhumbeni.

Ukuvezwa kwe-fibroblasts ku-Hexapeptide-11 umthamo othuthukisiwe kanye nokusebenza okuncike esikhathini kwe-proteasome, i-autophagy, i-chaperones kanye nezakhi zofuzo ezihlobene ne-antioxidant.Ngaphezu kwalokho, ikhuthaze ukunqwabelana kwenyukliya kwe-Nrf2;amazinga aphezulu e-proteasomal protein subunits kanye nemisebenzi eyandayo ye-proteasome peptidase.Ngokuhambisana nalokhu okutholakele siphawule ukuthi i-Hexapeptide-11 inikeze isivikelo esibalulekile kuma-fibroblasts ngokumelene ne-oxidative-stress-mediated senescence yamaselula ngaphambi kwesikhathi, kuyilapho ekuhlolweni kokuguqulwa kwesikhumba se-vivo ezifundweni zabantu kwathuthukisa ukunwebeka kwesikhumba.