I-Anti-aging Hexapeptide-11 CAS 161258-30-6 Ukunciphisa ukubonakala kwemibimbi
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Uphawu:
| Igama eliqhelekileyo | IHexapeptide-11 | Igama lesiNgesi | IHexapeptide-11 |
|---|---|---|---|
| Inombolo yeCAS | 161258-30-6 |
| Ifomula yemolekyuli | C36H48N6O7 |
|---|---|
| Ubunzima bemolekyuli | 676.80200 |
| Ubunzima obuchanekileyo | 676.35800 |
| PSA | 201.71000 |
| LogP | 4.09300 |
Ukusetyenziswa:
IHexapeptide-11 yimodyuli yenoveli yothungelwano lweproteostasis kwidiploid fibroblasts yabantu.
I-Hexapeptide-11 inciphisa ukubonakala kwemigca emihle kunye nemibimbi, ikwenza oku kongezwa okugqwesileyo kuzo zonke iintlobo zokhathalelo lwesikhumba kunye neemveliso ezichasene nokuguga.Ineseti eyodwa yee-amino acids ezinceda ekulawuleni amanqanaba e-collagen kunye nokunyusa ukuqina eluswini.
Ukubonakaliswa kwe-fibroblasts kwi-Hexapeptide-11 i-dose ephakanyisiweyo kunye nokusebenza okuxhomekeke kwixesha le-proteasome, i-autophagy, i-chaperones kunye neempendulo ze-antioxidant ezinxulumene nejene.Ngaphezu koko, ikhuthaze ukwanda kwenyukliya kwe-Nrf2;amanqanaba aphezulu okuchaza iproteasomal protein subunits kunye nokwandisa imisebenzi yeproteasome peptidase.Ngokuhambelana nolu phando siqaphele ukuba i-Hexapeptide-11 inikeze ukhuseleko olubalulekileyo kwi-fibroblasts ngokuchasene ne-oxidative-stress-mediated premature senescence yeselula, ngelixa kwi-vivo i-deformation yesikhumba kwizifundo zabantu iphucule ukuqina kolusu.
