I-CAS 52232-67-4 Teriparatide acetate Activator Teriparatide

CAS 52232-67-4 Teriparatide acetate Activator Teriparatide Featured Image

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Igama eliqhelekileyo:I-Teriparatide acetate

Inombolo yeCAS:52232-67-4

Ifomula yemolekyuli:C172H278N52O47S2

Ubunzima bemolekyuli:3890.49792

Indawo yokunyibilika:>205oC (ngoDisemba)

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Uphawu:

Igama eliqhelekileyo	I-Teriparatide Acetate	Igama lesiNgesi	I-pTH (1-34) (umntu) ityuwa ye-acetate
Inombolo yeCAS	52232-67-4

Ifomula yemolekyuli	C181H291N55O51S2
Ubunzima bemolekyuli	4177.77000
Iimpawu zenkangeleko	umgubo
Iimeko zokugcina	Itywiniwe, igcine kwi -20 ºC
Uzinzo	Akukho ukubola, akukho zimpendulo eziyingozi zaziwayo ukuba zisetyenziswe kwaye zigcinwe ngokweenkcukacha

Ukusetyenziswa:

I-Teriparatide yi-activator ye-PHT evuselela imveliso ye-G-protein cyclic monophosphate ehambelana nayo.

I-Teriparatide yaziwa ngokuba yi-hormone ye-parathyroid yabantu ephinda iphinda iphindwe (1-34) kwaye ibonisa iziphumo ze-anabolic kwithambo.I-Teriparatide lichiza elichasene ne-osteoporotic elisetyenziselwa ukunyanga i-osteoporosis;ayibonisi inzuzo ye-anti-resorptive, kodwa ivuselela ukubunjwa kwamathambo kunye nokwandisa amandla ethambo.I-Teriparatide yenza i-PTH1 receptor isebenze.Kwiisetingi zeklinikhi, i-teriparatide inciphisa ukwenzeka okutsha kokwaphuka kunye neentlungu zangasemva kwaye yonyusa i-lumbar spinal bone mineral density.Kwiiseli zestromal zamathambo empuku, i-teriparatide ilawula ukubonakaliswa kwe-osterix kunye ne-Runx2;kwiimodeli zezilwanyana ezidityanisiweyo, le khompawundi yonyusa ukuvuthwa kwe-osteoblast kwaye iphucula ukuphiliswa kokwaphuka.