I-CAS 52232-67-4 Teriparatide acetate Activator Teriparatide

incazelo emfushane:

Igama elijwayelekile:I-Teriparatide acetate

Inombolo ye-CAS:52232-67-4

Ifomula ye-molecular:I-C172H278N52O47S2

Isisindo samangqamuzana:3890.49792

Iphoyinti lokuncibilika:>205oC (dec.)

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Isici:

Igama elivamile	I-Teriparatide Acetate	Igama lesiNgisi	i-pTH (1-34) (umuntu) usawoti we-acetate
Inombolo ye-CAS	52232-67-4

Ifomula yamangqamuzana	C181H291N55O51S2
Isisindo samangqamuzana	4177.77000
Izici zokubukeka	impushana
Izimo zokugcina	Ivalwe, igcine ku -20 ºC
Ukuzinza	Akukho ukubola, akukho ukusabela okuyingozi okwaziwayo uma kusetshenziswa futhi kugcinwa ngokuya ngemininingwane

Ukusetshenziswa:

I-Teriparatide iyi-activator ye-PHT ekhuthaza ukukhiqizwa kwe-G-protein cyclic monophosphate ehlobene.

I-Teriparatide yaziwa nangokuthi i-hormone ye-parathyroid yomuntu ehlangene (1-34) futhi ibonisa imiphumela ye-anabolic emathanjeni.I-Teriparatide iyisidakamizwa esilwa ne-osteoporotic esetshenziswa emtholampilo ukwelapha i-osteoporosis;ayibonisi inzuzo ye-anti-resorptive, kodwa ivuselela ukwakheka kwamathambo futhi ikhulise amandla amathambo.I-Teriparatide yenza isamukeli se-PTH1 sisebenze.Ezilungiselelweni zomtholampilo, i-teriparatide inciphisa ukuphuka okusha nobuhlungu beqolo futhi ikhuphule ukuminyana kwamaminerali amathambo omgogodla we-lumbar.Kumaseli e-stromal amathambo egundane, i-teriparatide ilawula ukubonakaliswa kwe-osterix ne-Runx2;kumamodeli ezilwane ezibhanqiwe, le nhlanganisela ikhulisa ukuvuthwa kwe-osteoblast futhi ithuthukise ukuphulukiswa kokuphuka.