Manufacture supply Dihexa CAS 1401708-83-5

Usage:

DIHEXA (PNB-0408), a oligoplase reagent, is an IV analog of vascular tensionin IV with oral activity and blood-brain barrier permeability. Dihexa high-friendly and force combines hepatocyte growth factor (HGF), ChemicalBookkd value is 65PM, and enhances its activity to receptor C-MET. Dihexa shows excellent anti -ejaculation activity and improve cognitive functions in animal models. Dihexa has the potential to study Alzheimer's disease.

Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM.While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met.

Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity.Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons.