Qalabka wax-soo-saarka Dihexa CAS 1401708-83-5

Isticmaalka:

DIHEXA (PNB-0408), reagent oligoplase, waa analoogga IV ee xinjirowga xididdada IV ee leh dhaqdhaqaaqa afka iyo xannibaadda dhiigga-maskaxda.Dihexa-saaxiibtinimo sare iyo xoog waxay isku daraysaa factor koritaanka hepatocyte (HGF), KiimikadaBookkd qiimaha waa 65PM, oo kor u qaadaysa hawsheeda si ay u reseptor C-MET.Dihexa waxay muujinaysaa firfircoonida ka hortagga-baxa-baxa ee heer sare ah waxayna hagaajinaysaa hawlaha garashada ee moodooyinka xayawaanka.Dihexa waxay awood u leedahay inay barato cudurka Alzheimers.

Dihexa waxay ku xidhan tahay xidhiidh sare oo ay la leedahay HGF iyo labadaba dihexa iyo xarunteeda waalidka Norleucine 1-AngIV waxay dhalisaa c-Met fosforyaalka iyadoo ay jirto xad-hoosaadyada hoose ee HGF iyo kordhinta kala firdhisanaanta unugga ku tiirsan HGF.Dheeraad ah, dihexa iyo Nle1-AngIV waxay keenaan spinogenesis hippocampal iyo synaptogenesis oo la mid ah HGF lafteeda.Dihexa waxay si wax ku ool ah u joojisaa dhumucda HGF ee 1 μM. Halka dihexa at 1 nM iyo 10 pM kaliya ma hawlgelin c-Met, waxay si cad u kordhisaa awoodda HGF ee 1.25 iyo 2.5 ng/mL si loo dhaqaajiyo c-Met.

Dihexa waxay leedahay nolol badhkeed wareegaysa oo dheer.Dihexa waxa ay muujisaa firfircoonida garashada.Waxay wanaajisaa barashada boosaska jiirka da'da ah.Dihexa waxay keentaa spinogenesis ee neerfayaasha hippocampal ee dhaqameed.