Nrụpụta mmepụta Dihexa CAS 1401708-83-5

Ojiji:

DIHEXA (PNB-0408), a oligoplase reagent, bụ ihe analọgụ IV nke vascular tensionin IV na-arụ ọrụ ọnụ na ọbara-ụbụrụ mgbochi permeability.Dihexa elu-enyi na enyi na ike na-ejikọta hepatocyte growth factor (HGF), uru ChemicalBookkd bụ 65PM, ma kwalite ọrụ ya na onye na-anabata C-MET.Dihexa na-egosi ezigbo ọrụ mgbochi mmịpụta ma melite ọrụ ọgụgụ isi na ụdị anụmanụ.Dihexa nwere ikike ịmụ ọrịa Alzheimer.

Dihexa na-ejikọta ya na njikọ dị elu na HGF na ma dihexa na nne na nna ya Norleucine 1-AngIV na-ebute c-Met phosphorylation na ọnụnọ nke subthreshold mkpokọta nke HGF na augment HGF-adabere cell mgbasa.Ọzọkwa, dihexa na Nle1-AngIV na-ebute spinogenesis hippocampal na synaptogenesis yiri HGF n'onwe ya.Dihexa na-egbochi HGF dimerization nke ọma na 1 μM. Ọ bụ ezie na dihexa na 1 nM na 10 pM naanị adịghị arụ ọrụ c-Met, ọ na-eme ka ike HGF dị na 1.25 na 2.5 ng / mL rụọ ọrụ c-Met.

Dihexa nwere ọkara ndụ na-ekesa ogologo.Dihexa na-egosipụta ihe omume procognitive.Ọ na-eme ka mmụta gbasara ohere dị na oke oke.Dihexa na-ebute spinogenesis na neurons hippocampal omenala.