Ubonelelo lokwenziwa kweDihexa CAS 1401708-83-5

Ukusetyenziswa:

I-DIHEXA (i-PNB-0408), i-oligoplase reagent, i-analog ye-IV ye-vascular tensionin IV kunye nomsebenzi womlomo kunye ne-blood-brain barrier permeability.I-Dihexa i-high-friendly kunye ne-force idibanisa i-hepatocyte factor factor (HGF), ixabiso le-ChemicalBookkd yi-65PM, kwaye iphucula umsebenzi wayo kwi-receptor C-MET.I-Dihexa ibonisa umsebenzi ogqwesileyo wokulwa ne-ejaculation kunye nokuphucula imisebenzi yokuqonda kwiimodeli zezilwanyana.I-Dihexa inamandla okufunda isifo sika-Alzheimer.

I-Dihexa idibanisa kunye nobudlelwane obuphezulu kwi-HGF kunye zombini i-dihexa kunye nomzali wayo i-Norleucine 1-AngIV induce c-Met phosphorylation phambi kwe-subthreshold concentrations ye-HGF kunye nokwandisa i-HGF exhomekeke kwi-cell scattering.Ukuqhubela phambili, i-dihexa kunye ne-Nle1-AngIV yenza i-hippocampal spinogenesis kunye ne-synaptogenesis efana ne-HGF ngokwayo.I-Dihexa ivimbela ngokufanelekileyo i-HGF dimerization kwi-1 μM. Ngoxa i-dihexa kwi-1 nM kunye ne-10 pM yodwa ayisebenzisi i-c-Met, iphakamisa ngokuphawulekayo umthamo we-HGF kwi-1.25 kunye ne-2.5 ng / mL ukuze isebenze i-c-Met.

I-Dihexa inobomi obude obujikelezayo.I-Dihexa ibonisa umsebenzi wokuqonda.I-Dihexa ibuyisela ukusilela ekufundeni kwendawo exhomekeke kwi-scopolamine.Iphucula imfundo yendawo kwiimpuku ezindala.I-Dihexa yenza i-spinogenesis kwii-neuron ze-hippocampal ezikhuliswe.