Mea hana lako Dihexa CAS 1401708-83-5

Hoʻohana:

ʻO DIHEXA (PNB-0408), he oligoplase reagent, he mea hoʻohālikelike IV o ka vascular tensionin IV me ka hana waha a me ka pale ʻana i ke koko-lolo.Hoʻohui ʻia ʻo Dihexa kiʻekiʻe-aloha a me ka ikaika hepatocyte ulu kumu (HGF), ChemicalBookkd waiwai ʻo 65PM, a hoʻonui i kāna hana i ka loaʻa ʻana o C-MET.Hōʻike ʻo Dihexa i ka hana anti-ejaculation maikaʻi loa a hoʻomaikaʻi i nā hana cognitive i nā ʻano holoholona.Hiki iā Dihexa ke aʻo i ka maʻi o Alzheimer.

Hoʻopaʻa ʻo Dihexa me ka pilina kiʻekiʻe i ka HGF a me ka dihexa a me kāna hui makua ʻo Norleucine 1-AngIV e hoʻoulu i ka phosphorylation c-Met i mua o nā haʻahaʻa haʻahaʻa o ka HGF a hoʻonui i ka hoʻopuʻi ʻana o ka cell HGF.Eia hou, hoʻoulu ka dihexa a me Nle1-AngIV i ka spinogenesis hippocampal a me ka synaptogenesis e like me HGF pono'ī.Hoʻopau maikaʻi ʻo Dihexa i ka dimerization HGF ma 1 μM. ʻOiai ʻo dihexa ma 1 nM a me 10 pm wale nō ʻaʻole e hoʻāla i ka c-Met, hoʻonui nui ia i ka hiki o HGF ma 1.25 a me 2.5 ng/mL e hoʻāla i ka c-Met.

He lōʻihi ka hapalua o ke ola o Dihexa.Hōʻike ʻo Dihexa i ka hana procognitive. Hoʻohuli ʻo Dihexa i nā hemahema o ke aʻo ʻana i ka scopolamine.Hoʻomaikaʻi ia i ke aʻo ʻana i nā ʻiole kahiko.Hoʻokomo ʻo Dihexa i ka spinogenesis i nā neurons hippocampal moʻomeheu.