I-Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

Ama-peptide amathumbu e-Vasoactive, awaziwa nangokuthi ama-peptide amathumbu e-vasoactive noma i-VIP, angamahomoni e-peptide ane-vasoactive emathunjini.I-VIP iyi-peptide equkethe izinsalela ezingama-amino acid ezingama-28 okungeye-glucagon/secretin superfamily futhi iyi-ligand ye-Class II G yama-protein-coupled receptors.I-VIP ikhiqizwa ezicutshini eziningi zezilwane ezinomgogodla, okuhlanganisa amathumbu, amanyikwe, kanye ne-suprachiasmatic nucleus ye-hypothalamus yobuchopho.I-VIP ivuselela ukufinyela kwenhliziyo, ibangele i-vasodilation, ikhuphule ukuwohloka kwe-glycogen, yehlise umfutho wegazi we-arterial futhi iphumuze imisipha ebushelelezi kuqhoqhoqho, esiswini kanye nesinye.Kubantu, ama-peptide amathumbu e-vasoactive afakwe ikhodi yezakhi zofuzo ze-VIP.

Ingxenye yempilo (t ½) ye-VIP egazini cishe imizuzu emibili.

I-VIP inomthelela ezinhlanganweni ezahlukahlukene:

Ohlelweni lokugaya ukudla, i-VIP ibonakala ibangela ukuxegiswa kwemisipha ebushelelezi (i-low esophageal sphincter, isisu, i-gallbladder), ivuselele ukuthungwa kwamanzi ku-pancreatic fluid kanye ne-bile, futhi ivimbele ukuthungwa nokumuncwa kwe-asidi yesisu ephuma emgodini wamathumbu.Iqhaza layo emathunjini iwukugqugquzela kakhulu ukukhishwa kwamanzi nama-electrolyte, kanye nokuphumuza imisipha yamathumbu abushelelezi, ukunweba imithambo yegazi ejikelezayo, kugqugquzele ukukhishwa kwe-bicarbonate ngamanyikwe futhi kuvimbele ukuvela kwe-gastrin-stimulated gastric acid.Le miphumela isebenza ndawonye ukuze kwandiswe i-motility.Iphinde ikhuthaze ukukhiqizwa kwe-pepsinogen ngeseli eliyinhloko.I-VIP ibonakala iyi-neuropeptide ebalulekile ngesikhathi sokugula kwamathumbu okuvuvukala ngoba ukuxhumana kwe-mast cell kanye ne-VIP kulawulwa yi-colitis efana nesifo sika-Crohn.

Ikhona futhi enhliziyweni futhi inomthelela omkhulu ohlelweni lwenhliziyo.Ibangela i-coronary vasodilation futhi inemiphumela emihle ye-inotropic ne-chronotropic.Kuqhutshwa ucwaningo lokunquma ukuthi unawo yini umphumela onenzuzo ekwelapheni ukuhluleka kwenhliziyo.I-VIP igqugquzela ukugcotshwa kwesitho sangasese sowesifazane kwabesifazane abavamile, iphinda kabili inani eliphelele lokuthambisa elikhiqizwayo