Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

Vasoactive intestinal peptides, inozivikanwawo sevasoactive intestinal peptides kana VIP, mahomoni epeptide ari vasoactive mumatumbo.VIP ipeptide ine 28 amino acid zvisaririra zviri zveglucagon/secretin superfamily uye iri ligand yeClass II G protein-coupled receptors.VIP inogadzirwa mune dzakawanda vertebrate tishu, kusanganisira ura, pancreas, uye suprachiasmatic nucleus yehuropi hypothalamus.VIP inokurudzira kubatwa kwemwoyo, inokonzera vasodilation, inowedzera kuparara kweglycogen, inoderedza arterial blood pressure uye inozorodza tsandanyama dzakatsetseka mutrachea, mudumbu uye gallbladder.Muvanhu, vasoactive intestinal peptides yakavharwa neVIP genes.

Hafu yeupenyu (t ½) yeVIP muropa ingangoita maminetsi maviri.

VIP ine chekuita kune akasiyana masangano:

Muchirongwa chekudya, VIP inoratidzika kunge inokonzera kuzorora kwemhasuru yakatsetseka (pasi esophageal sphincter, dumbu, gallbladder), inokurudzira kubuda kwemvura mupancreatic fluid uye bile, uye inhibit secretion uye kutorwa kwegastric acid kubva mudumbu remukati.Basa rayo mudumbu nderekukurudzira zvakanyanya kuvharwa kwemvura uye electrolytes, pamwe nekuzorodza mudumbu mutsetse wakatsetseka, kuwedzera tsinga dzeropa, kukurudzira secretion yebicarbonate nepancreas uye inhibit gastrin-inosimudzira gastric acid secretion.Izvi mhedzisiro zvinoshanda pamwechete kuwedzera motility.Inokurudzirawo kugadzirwa kwepepsinogen nesero guru.VIP inoita seyakakosha neuropeptide panguva yekuzvimba bowel chirwere nekuti mast cell uye VIP kutaurirana kunodzorwa mucolitis senge chirwere cheCrohn.

Inowanikwawo mumoyo uye ine simba guru pahutano hwemwoyo.Inokonzera coronary vasodilation uye ine yakanaka inotropic uye chronotropic madhara.Tsvagiridzo iri kuitika yekuona kana ine mhedzisiro inobatsira mukurapa kukundikana kwemoyo.VIP inomutsa mafuta ekugezera muvakadzi vakakwana, zvichipeta kaviri huwandu hwese hwekuzora hunogadzirwa