Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE
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Tšebeliso
Li-peptide tsa mala a vasoactive, tse tsejoang hape e le vasoactive intestinal peptides kapa VIP, ke lihomone tsa peptide tse nang le vasoactive ka maleng.VIP ke peptide e nang le masalla a 28 a amino acid ao e leng a superfamily ea glucagon/secretin 'me ke ligand tsa Class II G protheine-coupled receptors.VIP e hlahisoa ka har'a lisele tse ngata tse nang le lesapo la mokokotlo, ho kenyeletsoa mala, manyeme, le khubu e kholo ea hypothalamus ea boko.VIP e hlohlelletsa ho honyela ha pelo, e baka vasodilation, e eketsa ho senyeha ha glycogen, e theola khatello ea mali le ho khatholla mesifa e boreleli ea trachea, mpeng le nyooko.Ho batho, li-peptide tsa mala a vasoactive li kentsoe ka liphatsa tsa lefutso tsa VIP.
Halofo ea bophelo (t ½) ea VIP maling ke metsotso e ka bang peli.
VIP e na le tšusumetso mekhatlong e fapaneng:
Tsamaisong ea tšilo ea lijo, VIP e bonahala e baka phomolo ea mesifa e boreleli (e ka tlaase ea esophageal sphincter, mala, gallbladder), e susumetsang ho ntšoa ha metsi ka har'a mokelikeli oa pancreatic le bile, 'me e thibela ho tsoa le ho monya ha acid ea gastric ho tloha ka mpeng ea mala.Karolo ea eona ka maleng ke ho matlafatsa secretion ea metsi le li-electrolyte haholo, hammoho le ho phomotsa mesifa e boreleli ea mala, ho holisa methapo ea mali, ho hlohlelletsa secretion ea bicarbonate ke manyeme le ho thibela secretion ea gastrin-stimulated gastric acid.Liphello tsena li sebetsa 'moho ho eketsa motility.E boetse e susumetsa tlhahiso ea pepsinogen ke sele e kholo.VIP e bonahala e le neuropeptide ea bohlokoa nakong ea lefu la ho ruruha ha mala hobane puisano ea mast cell le VIP e laoloa ho colitis e kang lefu la Crohn.
E boetse e teng ka pelong 'me e na le phello e kholo tsamaisong ea pelo.E baka vasodilation ea pelo mme e na le litlamorao tse ntle tsa inotropic le chronotropic.Patlisiso e ntse e tsoela pele ho fumana hore na e na le phello e molemo ho phekoleng ho hloleha ha pelo.VIP e hlohlelletsa ho tlotsa ka botšehaling ho basali ba tloaelehileng, ho imena habeli palo eohle ea mafura a hlahisoang
