Vasoactive Intestinal Peptide CAS: 40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

Peptide yo mu nda ya Vasoactive, izwi kandi nka peptide ya vasoactive intestinal peptide cyangwa VIP, ni imisemburo ya peptide iba vasoactive munda.VIP ni peptide irimo ibisigisigi 28 bya aminide acide ya glucagon / secretine birenze urugero kandi ni ligand ya proteine ​​yo mu cyiciro cya II G hamwe na reseptor.VIP ikorerwa mubice byinshi byintangangabo, harimo amara, pancreas, na nucleus suprachiasmatic ya hypothalamus yubwonko.V.Mu bantu, peptide yo mu nda ya vasoactive iba igizwe na gen.

Igice cya kabiri cyubuzima (t ½) cya VIP mumaraso ni iminota ibiri.

VIP igira ingaruka kumiryango itandukanye:

Muri sisitemu y'ibiryo, VIP isa naho itera kuruhura imitsi yoroshye (sphincter yo hepfo ya esophageal, igifu, gallbladder), itera gusohora amazi mumazi ya pancreatic na bile, kandi ikabuza gusohora no kwinjiza aside gastrica kuva munda y'amara.Uruhare rwayo mu mara ni ugukangurira cyane gusohora amazi na electrolytite, ndetse no kuruhura imitsi yoroshye yo mu mara, kwagura imiyoboro y'amaraso ya periferique, gutera ururenda rwa bicarbonate na pancreas no kubuza gusohora gastrine iterwa na gastricine.Izi ngaruka zikorana kugirango zongere umuvuduko.Itera kandi gusohora pepsinogen na selile nkuru.VIP isa nkaho ari neuropeptide ikomeye mugihe cyindwara zifata amara kuko selile ya mast na VIP itunganijwe neza muri colitis nkindwara ya Crohn.

Iraboneka kandi mumutima kandi igira ingaruka zikomeye kuri sisitemu yumutima.Itera coronary vasodilation kandi ifite ingaruka nziza za inotropique na chronotropique.Ubushakashatsi burimo gukorwa kugirango hamenyekane niba bifite ingaruka nziza mukuvura kunanirwa k'umutima.VIP itera amavuta yo mu gitsina ku bagore basanzwe, ikubye kabiri amavuta yose yatanzwe