Vasoactive Intestinal Peptide CAS:40077-57-4 VASOACTIVE INTESTINAL PEPTIDE, PORCINE VASOACTIVE INTESTINAL PEPTIDE

Vasoactive intestinal peptides, omwe amadziwikanso kuti vasoactive intestinal peptides kapena VIP, ndi mahomoni a peptide omwe ali ndi vasoactive m'matumbo.VIP ndi peptide yomwe ili ndi zotsalira 28 za amino acid zomwe zili m'gulu la glucagon/secretin superfamily ndipo ndi ligand of Class II G protein-coupled receptors.VIP imapangidwa m'magulu ambiri amtundu wa vertebrate, kuphatikizapo m'matumbo, kapamba, ndi nyukiliya ya suprachiasmatic ya hypothalamus ya ubongo.VIP imathandizira kugundana kwa mtima, imayambitsa vasodilation, imawonjezera kuwonongeka kwa glycogen, imachepetsa kuthamanga kwa magazi ndikutsitsimutsa minofu yosalala mu trachea, m'mimba ndi ndulu.Mwa anthu, vasoactive matumbo peptides ndi encoded ndi VIP majini.

Theka la moyo (t ½) wa VIP m'magazi ndi pafupifupi mphindi ziwiri.

VIP imakhudza mabungwe osiyanasiyana:

M'matumbo a m'mimba, VIP ikuwoneka kuti imayambitsa kupumula kwa minofu yosalala (m'munsi esophageal sphincter, m'mimba, ndulu), imapangitsa kuti madzi asungunuke mu pancreatic fluid ndi bile, ndikulepheretsa kutuluka ndi kuyamwa kwa gastric acid kuchokera m'matumbo.Ntchito yake m'matumbo ndikulimbikitsa kwambiri katulutsidwe ka madzi ndi ma electrolyte, komanso kupumula minofu yosalala ya m'matumbo, kukulitsa mitsempha yamagazi, kulimbikitsa kutulutsa kwa bicarbonate ndi kapamba ndikuletsa kutulutsa kwa gastrin-stimulated gastric acid.Zotsatirazi zimagwira ntchito limodzi kuti ziwonjezere kuyenda.Imathandizanso kutulutsa kwa pepsinogen ndi cell yayikulu.VIP ikuwoneka ngati neuropeptide yofunikira panthawi ya matenda otupa chifukwa mast cell ndi VIP kulankhulana kumayendetsedwa ndi colitis monga matenda a Crohn.

Imapezekanso mu mtima ndipo imakhudza kwambiri dongosolo la mtima.Zimayambitsa coronary vasodilation ndipo zimakhala ndi zotsatira zabwino za inotropic ndi chronotropic.Kafukufuku akuchitika kuti adziwe ngati ili ndi phindu pochiza kulephera kwa mtima.VIP imapangitsa mafuta kumaliseche mwa amayi abwinobwino, kuwirikiza kawiri kuchuluka kwamafuta opangidwa