Vasoactive intestinal Peptide CAS: 40077-57-4 VASOACTIVE INTEESTINAL PEPTIDE, PORCINE VASOACTIVE INTEESTINAL PEPTIDE.

Vasoactive intestinal peptides, nke a makwaara dị ka peptides intestinal vasoactive ma ọ bụ VIP, bụ homonụ peptide na-eme vasoactive na eriri afọ.VIP bụ peptide nwere ihe fọdụrụ amino acid 28 bụ nke glucagon/secretin superfamily ma bụrụ njikọ nke klas II G protein jikọtara ọnụ.A na-emepụta VIP n'ọtụtụ anụ ahụ vertebrate, gụnyere eriri afọ, pancreas, na suprachiasmatic nucleus nke ụbụrụ hypothalamus.VIP na-akpali mkpụkọ obi, na-akpata vasodilation, na-abawanye ndakpọ glycogen, na-ebelata ọbara mgbali elu ma na-eme ka uru ahụ dị nro dị na trachea, afo na gallbladder.N'ime mmadụ, mkpụrụ ndụ ihe nketa VIP na-etinye peptides intestinal vasoactive.

Ọkara ndụ (t ½) nke VIP n'ime ọbara dị ihe dị ka nkeji abụọ.

VIP nwere mmetụta na ụlọ ọrụ dị iche iche:

N'ime usoro nri nri, VIP na-egosi na ọ na-eme ka ahụ ike dị nro (shincter esophageal dị ala, afo, gallbladder), na-akpali nzuzo nke mmiri n'ime mmiri pancreatic na bile, na-egbochi nzuzo na absorption nke gastric acid site na oghere eriri afọ.Ọrụ ya n'ime eriri afọ bụ ịkpali nzuzo nke mmiri na electrolytes nke ukwuu, yana mee ka ahụ dị nro dị nro dị nro nke eriri afọ, gbasaa arịa ọbara, kpalie nzuzo nke bicarbonate site na pancreas ma gbochie secretion gastric acid na-akpali akpali.Mmetụta ndị a na-arụkọ ọrụ ọnụ iji mụbaa motility.Ọ na-akpalikwa nzuzo nke pepsinogen site na isi cell.VIP na-egosi na ọ bụ neuropeptide dị mkpa n'oge ọrịa bowel na-egbuke egbuke n'ihi na a na-edozi mast cell na nkwurịta okwu VIP na colitis dị ka ọrịa Crohn.

Ọ dịkwa n'ime obi ma nwee mmetụta dị ukwuu na usoro obi.Ọ na-akpata vasodilation nke akwara obi ma nwee mmetụta inotropic na chronotropic dị mma.A na-eme nyocha iji chọpụta ma ọ nwere mmetụta bara uru n'ịgwọ nkụda obi.VIP na-akpali mmanu mmanu n'ime ụmụ nwanyị nkịtị, na-eme ka mmanu mmanu na-abawanye okpukpu abụọ