Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE.

Nonoreceptor / orphenkephalin FQ (N / OFQ) bụ 17-amino acid neuropeptide nke bụ njikọ endogenous nke nonoreceptor (ORL-1).Nociceptive peptide, dị ka ọgwụ mgbochi analgesic dị irè, nwere ike igbochi mmetụta nke ọgwụ mgbu.Ejikọtala ntinye ya na ọrụ ụbụrụ dị ka nghọta mgbu na mmụta egwu.

Koodu mkpụrụ ndụ ihe nketa maka prepronociceptin dị na mmadụ Ch8p21.A na-enweta peptides na-emetụ n'ahụ mgbu site na protein peptide propain, yana peptides abụọ ọzọ, nocistatin na NocII, nke abụọ na-egbochi ọrụ nnabata N / OFQ.Nociceptin bụ ihe atụ mbụ nke reverse pharmacology;Achọpụtara onye na-anabata NOP tupu achọpụtara ligands endogenous site na otu abụọ dị iche iche na 1995.

N'ime ọmụmụ anụmanụ, a chọpụtakwara ụzọ nnabata N/OFQ-NOP ka ọ na-arụ ọrụ dị mma na nke na-adịghị mma na mmụta na ebe nchekwa.Dịka ọmụmaatụ, ejikọtala ndakpọ n'ụzọ a na mgbanwe nke mmụta egwu na nsogbu ụbụrụ dị ka nsogbu nrụgide post-traumatic (PTSD).Ya mere, ụzọ ndị nnata na-edobe nzaghachi homeostasis maka egwu na ọnọdụ nrụgide.Nociceptor nwekwara ike ịrụ ọrụ mgbochi na ọrụ ebe nchekwa, dịka ụfọdụ ọmụmụ egosila na ọ na-emebi mmụta gbasara ohere na vivo ma na-egbochi nkwalite ogologo oge na nnyefe synapti na vitro.