Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

Nonoreceptor / orphenkephalin FQ (N / OFQ) o se 17-amino acid neuropeptide o se ligand endogenous o nonoreceptor (ORL-1).Nociceptive peptide, o se vailaʻau faʻamaʻi faʻamaʻi, e mafai ona faʻafetaui lelei le aʻafiaga o faʻamaʻi tiga.O lona fa'agaoioia ua feso'ota'i atu i galuega fai'ai e pei o le lagona o le tiga ma le a'oa'oina o le fefe.

Ole genetic code mo prepronociceptin o loʻo i luga ole tagata Ch8p21.Peptides maaleale tiga e maua mai i le propain sensitive peptide proteins, faatasi ai ma isi peptides e lua, nocistatin ma NocII, o ia mea uma e taofia ai le N / OFQ receptor function.O le Nociceptin o le fa'ata'ita'iga muamua lea o le fa'afoma'i fa'afoma'i;O le NOP receptor na maua aʻo leʻi mauaina le ligands endogenous e lua vaega eseese i le 1995

I suʻesuʻega a manu, o le N/OFQ-NOP ala talipupuni ua maua foʻi e faʻatino uma tulaga lelei ma le le lelei i le aʻoaʻoina ma le manatua.Mo se faʻataʻitaʻiga, o faʻalavelave i lenei auala ua fesoʻotaʻi ma suiga i le fefe e aʻoaʻoina i faʻafitauli o le faiʻai e pei o le post-traumatic stress disorder (PTSD).O le mea lea, o auala faʻafeiloaʻi e faʻamautu ai tali o le homeostasis i le fefe ma tulaga faʻalavelave.E mafai foi e le Nociceptor ona faia se sao faʻalavelave i le mafaufau, e pei ona faʻaalia e nisi o suʻesuʻega e faʻaleagaina ai le aʻoaʻoina o le vateatea i vivo aʻo faʻalavelaveina le faʻaleleia o taimi uumi ma le synaptic transmission in vitro