Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

inkcazelo emfutshane:

INOMBOLO YECASS:170713-75-4

Igama:Nociceptin

Ubuninzi :1.47±0.1 g/cm3(Kuxelwe kwangaphambili)

pka:3.19±0.10(Kuqikelelwe)

ixesha lokugcina.:−20°C

Ifomula yemichiza:I-C79H129N27O22

ifom:umgubo

Ubunzima beMolar:1809.04

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Ukusetyenziswa

I-Nonoreceptor / orphenkephalin FQ (N / OFQ) yi-17-amino acid neuropeptide eyi-endogenous ligand ye-nonoreceptor (ORL-1).I-peptide ye-nociceptive, njenge-anti-analgesic drug esebenzayo, inokuchasana ngokufanelekileyo nomphumo we-painkillers.Ukusebenza kwayo kudityaniswe nemisebenzi yengqondo efana nokuqonda intlungu kunye nokufunda ukwesaba.

Ikhowudi yofuzo ye-prepronociceptin ifumaneka kwi-Ch8p21 yomntu.Iipeptide ezibuthathaka kwintlungu zisuka kwiprotein ye-peptide ebuthathaka, kunye nezinye iipeptide ezimbini, i-nocistatin kunye ne-NocII, zombini ezithintela umsebenzi we-N/OFQ we-receptor.I-Nociceptin yayingumzekelo wokuqala we-pharmacology ye-reverse;I-NOP receptor yafunyanwa ngaphambi kokufunyanwa kwe-ligands engapheliyo ngamaqela amabini ahlukeneyo kwi-1995.

Kwizifundo zezilwanyana, indlela ye-N/OFQ-NOP ye-receptor nayo ifunyenwe ukuba idlale indima enhle kunye nembi ekufundeni nasekukhumbuleni.Ngokomzekelo, ukuchithwa kule ndlela kuye kwadibaniswa nokuguqulwa koloyiko lokufunda kwiingxaki zengqondo ezifana ne-post-traumatic stress disorder (PTSD).Ngaloo ndlela, iindlela ze-receptor zigcina iimpendulo ze-homeostasis kuloyiko kunye neemeko ezixinzelelekileyo.I-Nociceptor inokuphinda idlale indima yokuthintela ekusebenzeni kwememori, njengoko ezinye izifundo zibonise ukuba ziphazamisa ukufunda kwendawo kwi-vivo ngelixa zivimbela ukuphuculwa kwexesha elide kunye nokuhanjiswa kwe-synaptic in vitro.