Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE
Ikoreshwa
Nonoreceptor / orphenkephalin FQ (N / OFQ) ni 17-amino acide neuropeptide ni ligand ya endogenous ya nonoreceptor (ORL-1).Peptide ya Nociceptive, nk'umuti mwiza wa antianalgesic, urashobora kurwanya neza ingaruka ziterwa n'imiti.Gukora kwayo byahujwe nibikorwa byubwonko nko kumva ububabare no kwiga ubwoba.
Kode ya genetike ya prepronociceptin iri kuri Ch8p21 yabantu.Ububabare bworoshye peptide bukomoka kuri poroteyine yoroheje ya peptide, hamwe nizindi peptide ebyiri, nocistatine na NocII, byombi bikabuza imikorere ya N / OFQ.Nociceptin yari urugero rwambere rwa farumasi ihinduka;Reseptor ya NOP yavumbuwe mbere yo kuvumbura endogenous ligands n'amatsinda abiri atandukanye mu 1995
Mu bushakashatsi bw’inyamaswa, inzira ya reseptor ya N / OFQ-NOP nayo yasanze igira uruhare runini kandi rwiza mukwiga no kwibuka.Kurugero, gusenyuka muriyi nzira byahujwe no guhinduka mugutinya kwiga mubibazo byubwonko nka disikuru nyuma yo guhahamuka (PTSD).Rero, inzira ya reseptor ikomeza homeostasis ibisubizo kubibazo byubwoba nibibazo bitesha umutwe.Nociceptor irashobora kandi kugira uruhare runini mu mikorere yo kwibuka, kuko ubushakashatsi bumwe bwerekanye ko bubangamira imyigire y’ahantu muri vivo mu gihe ibuza kuzamura igihe kirekire no kwanduza synaptic muri vitro
