Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

wehewehe pōkole:

NO KA CAS:170713-75-4

inoa:Nociceptin

mānoanoa :1.47±0.1 g/cm3(Wānana ʻia)

pka:3.19±0.10(Wanamua)

ka mahana mālama.:−20°C

ʻO ke kumu hoʻohālikelike:C79H129N27O22

ʻano:pauda

Nuipa mola:1809.04

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ʻO Nonoreceptor / orphenkephalin FQ (N / OFQ) he 17-amino acid neuropeptide he ligand endogenous o nonoreceptor (ORL-1).Nociceptive peptide, ma ke ʻano he lāʻau antianalgesic maikaʻi, hiki ke pale maikaʻi i ka hopena o nā ʻeha.Ua hoʻopili ʻia kona hoʻāla ʻana i nā hana o ka lolo e like me ka ʻike ʻeha a me ke aʻo makaʻu.

Aia ke code genetic no prepronociceptin ma ke kanaka Ch8p21.Loaʻa ʻia nā peptides ʻeha mai ka propain sensitive peptide protein, me ʻelua mau peptides ʻē aʻe, nocistatin a me NocII, nā mea ʻelua e pale ai i ka hana receptor N/OFQ.ʻO Nociceptin ka hiʻohiʻona mua o ka pharmacology reverse;Uaʻikeʻia ka NOP receptor ma mua o ka loaʻaʻana o nā ligands endogenous e nā hui likeʻole ma 1995.

Ma nā haʻawina holoholona, ua ʻike ʻia ke ala ʻae N/OFQ-NOP e pāʻani i nā kuleana maikaʻi a maikaʻi ʻole i ke aʻo ʻana a me ka hoʻomanaʻo.No ka laʻana, ua hoʻopili ʻia nā haʻihaʻi ma kēia ala i nā hoʻololi ʻana i ke aʻo ʻana i ka makaʻu i nā maʻi lolo e like me ka post-traumatic stress disorder (PTSD).No laila, mālama nā ala o ka mea hoʻokipa i nā pane homeostasis i ka makaʻu a me nā kūlana koʻikoʻi.Hiki i ka Nociceptor ke pāʻani i ka hana hoʻomanaʻo i ka hana hoʻomanaʻo, e like me ka hōʻike ʻana o kekahi mau haʻawina e hōʻemi ana i ka aʻo ʻana i ka spatial in vivo ʻoiai ke kāohi nei i ka hoʻonui lōʻihi a me ka hoʻouna synaptic in vitro