Izitshalo zezitshalo zemvelo CAS 51-34-3 Scopolamine

I-Scopolamine(i-hyoscine) itholakala kumalungu ahlukahlukene e-Solanaceae (isb, i-H. niger, i-Duboisia myoporoides, i-Scopolia spp., ne-Datura metel).I-Scopolamine ngokuvamile ihlukaniswa notshwala kamama obusele ekuhlukaniseni i-hyoscyamine.

I-Hyoscine igama elidala lale alkaloid, nakuba i-scopolamine kuyigama elamukelekayo e-United States.I-Scopolamine iyingxenye ye-levo yengxube ye-racemic eyaziwa ngokuthi i-atroscine.I-alkaloid ihlukaniswa kalula lapho kukhona i-alkali encibilikayo.

I-alkaloid yenzeka ngendlela ye-levorotatory, viscousliquid encibilika kancane kuphela emanzini kodwa encibilika kakhulu kutshwala, i-chloroform, noma i-ether.Yakha usawoti oyikristale ngama-asidi amaningi, kanti i-hydrobromide iyona ezinze kakhulu futhi eyamukelwa kakhulu.Isixazululo esinamanzi se-hydrobromide esiqukethe u-10% we-mannitol kuthiwa asijwayele ukubola kunezixazululo ezingavikelekile.

I-Pharmacology

I-Scopolamine butylbromide, i-scopolamine eguquliwe, iyisidakamizwa se-peripheral anti-choline;ayigcini nje ngokushelela i-muscle spasm kodwa futhi ivimbela i-ganglion ne-neuromuscular junction futhi inomphumela obuthakathaka phakathi nendawo.Lesi sidakamizwa sinemiphumela enamandla ku-spasm yemisipha ebushelelezi yamathumbu kune-atropine ne-anisodamine;ingadambisa ngokukhetha umgudu wamathumbu, umgudu webiliary, kanye ne-urinary tract smooth muscle spasm futhi ivimbele i-peristalsis yayo.

I-Scopolamine butylbromide inemiphumela emincane enhliziyweni, kumfundi, nendlala yamathe, ngakho-ke ayivamisile ukubangela ukujabula kwemizwa emaphakathi, ukunwebeka, ukuvimbela ukuphuma kwamathe, nokunye ukusabela okungekuhle, okungafani ne-atropine.

I-Scopolamine butylbromide iphikisana ne-M cholinergic receptor, imiphumela yayo ye-pharmacological ifana ne-atropine, kodwa inezici zayo ezinenzuzo esobala ekuthuthukiseni i-microcirculation yegazi.