Tsire-tsire na halitta yana fitar da CAS 51-34-3 Scopolamine

Scopolamine(hyoscine) ana samunsa a cikin mambobi daban-daban na Solanaceae (misali, H. niger, Duboisia myoporoides, Scopolia spp., da Datura metel).Scopolamine yawanci keɓe daga uwar barasa da ta rage daga keɓewar hyoscyamine.

Hyoscine shine tsohuwar sunan wannan alkaloid, kodayake scopolamine shine sunan da aka karɓa a cikin Amurka. Scopolamine shine ɓangaren levo na cakuda tseren tsere wanda aka sani da atroscine.A alkaloid ne racemized readily gaban dilute alkali.

Alkaloid yana faruwa a cikin nau'i na levorotatory, viscousliquid wanda yake dan kadan ne kawai a cikin ruwa amma barasa mai narkewa sosai, chloroform, ko ether.Yana samar da salts crystalline tare da yawancin acid, tare da hydrobromide shine mafi kwanciyar hankali kuma mafi karɓa.Maganin ruwa mai ruwa na hydrobromide mai ɗauke da 10% mannitol an ce ba shi da lahani ga ruɓe fiye da hanyoyin da ba su da kariya.

Ilimin harhada magunguna

Scopolamine butylbromide, wani gyare-gyaren scopolamine, maganin maganin choline ne na gefe;shi ba kawai zai iya santsi spasm tsoka amma kuma toshe ganglion da neuromuscular junction kuma yana da rauni tasiri a kan cibiyar.Wannan miyagun ƙwayoyi yana da tasiri mai ƙarfi akan spasm mai santsi na hanji fiye da atropine da anisodamine;yana iya zaɓin sauƙaƙe ƙwayar gastrointestinal, biliary tract, da urinary tract santsin tsoka da kuma hana peristalsis.

Scopolamine butylbromide yana da ƙarancin tasiri akan zuciya, almajiri, da gland mai salivary, don haka da wuya yana haifar da tashin hankali na tsakiya, dilation, hana zubar jini, da sauran halayen mara kyau, wanda ba kamar atropine ba.

Scopolamine butylbromide antagonist ne na mai karɓa na M cholinergic, tasirinsa na harhada magunguna yana kama da atropine, amma yana da nasa halaye waɗanda ke da fa'ida a bayyane wajen haɓaka microcirculation na jini.