Zomera zachilengedwe zachilengedwe CAS 51-34-3 Scopolamine

Scopolamine(hyoscine) imapezeka m'magulu osiyanasiyana a Solanaceae (mwachitsanzo, H. niger, Duboisia myoporoides, Scopolia spp., ndi Datura metel).Scopolamine nthawi zambiri imapatulidwa ndi chakumwa cha mayi chomwe chimatsalira pakudzipatula kwa hyoscyamine.

Hyoscine ndi dzina lakale la alkaloid iyi, ngakhale scopolamine ndi dzina lovomerezeka ku United States.The alkaloid ndi racemized mosavuta pamaso pa dilute alkali.

Alkaloid imapezeka ngati levorotatory, viscousliquid yomwe imasungunuka pang'ono m'madzi koma mowa wosungunuka kwambiri, chloroform, kapena ether.Amapanga mchere wa crystalline wokhala ndi ma asidi ambiri, ndipo hydrobromide imakhala yokhazikika komanso yovomerezeka kwambiri.Mankhwala amadzimadzi a hydrobromide okhala ndi 10% mannitol akuti ndi osawonongeka pang'ono poyerekeza ndi osatetezedwa.

Pharmacology

Scopolamine butylbromide, scopolamine yosinthidwa, ndi peripheral anti-choline mankhwala;Sikuti imatha kusalala minofu komanso kutsekereza ganglion ndi neuromuscular junction ndipo imakhala ndi mphamvu yofooka pakati.Mankhwalawa ali ndi zotsatira zamphamvu pamatumbo osalala a minofu kuposa atropine ndi anisodamine;amatha kuthetsa m'mimba, thirakiti la biliary, ndi thirakiti la mkodzo, komanso kutsekeka kwa minofu yosalala ndikulepheretsa peristalsis yake.

Scopolamine butylbromide imakhala ndi zotsatira zochepa pamtima, mwana, ndi gland ya salivary, choncho nthawi zambiri imayambitsa chisangalalo chapakati, kusungunuka, kulepheretsa kutuluka kwa malovu, ndi zina zoyipa zomwe zimasiyana ndi atropine.

Scopolamine butylbromide ndi wotsutsana ndi M cholinergic receptor, zotsatira zake za pharmacological ndizofanana ndi atropine, koma zimakhala ndi makhalidwe ake omwe ali ndi ubwino wodziwikiratu pakuwongolera microcirculation ya magazi.