I-Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide
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Isici:
| Igama elivamile | I-Exenatide | Igama lesiNgisi | Exenatide acetate usawoti |
|---|---|---|---|
| Inombolo ye-CAS | 141758-74-9 |
| Ifomula yamangqamuzana | I-C184H282N50O60S |
|---|---|
| Isisindo samangqamuzana | 4186.57000 |
| Isisindo esinembile | 4184.03000 |
| I-PSA | 1775.05000 |
| Izimo zokugcina | Ivaliwe, igcinwe ku-20ºC |
| Ukuzinza | Akukho ukubola, akukho ukusabela okuyingozi okwaziwayo uma kusetshenziswa futhi kugcinwa ngokuya ngemininingwane |
Ukusetshenziswa:
I-Exenatide ingumuthi wokuqala ekilasini elisha le-antidiabetesic elaziwa ngokuthi i-incretin mimetics, futhi ikhonjiswa njengokwelashwa okungeziwe ukuze kuthuthukiswe ukulawulwa kwe-glycemic ezigulini ezinesifo sikashukela sohlobo 2 ezithatha i-metformin, i-sulfonylurea, noma zombili, kodwa zingakayitholi. ithole ukulawulwa okwanele kwe-glycemic.I-Exenatide iyi-analog esebenzayo ye-incretin yomuntu iGlucagon-Like Peptide-1 (GLP-1).I-GLP-1 ikhishwa ngokwemvelo kumaseli epheshaneni le-GI ukuphendula ukudla okudlayo futhi isebenza ku-receptor yayo kuma-b-cell ukuze iqinise ukukhiqizwa kwe-insulin evuselelwe i-glucose.I-Exenatide iyi-agonist esebenza isikhathi eside kuma-GLP-1 receptor.Iwuhlobo lokwenziwa lwe-peptide engu-39-amino acid etholakala ekukhiqizweni kwamathe e-Gila monster lizard.iphinda ilinganise amazinga aphezulu e-serum glucagon ngezikhathi ze-hyperglycemic ngemva kokudla, kodwa ayiphazamisi ukukhululwa kweglucagon ukuphendula ku-hypoglycemia.Umuthi womthamo we-exenatide ngu-5 noma 10 mg kabili ngosuku, uphathwa njengomjovo ongaphansi kwesikhumba kungakapheli ihora ngaphambi kokudla kwasekuseni nakusihlwa.Ngemuva kokuphathwa kwe-subcutaneous, ukugxila okuphezulu kwe-exenatide ku-plasma kufinyelelwa emahoreni angama-2.1, kanti iphrofayili ye-pharmacokinetic ye-plasma ilingana nomthamo.Izehlakalo ezimbi ezivame kakhulu ezibikwa nge-exenatide zihlanganisa isicanucanu, ukuhlanza, isifo sohudo, ukuzizwa unesizungu, isiyezi, ikhanda elibuhlungu kanye ne-dyspepsia.
I-Exendin-4 ingakwazi ukwenza i-GLP-1 receptor isebenze, i-receptor ingakhuphula amazinga e-cAMP amaseli e-pancreatic acinar ku-intracellular, kodwa ayinawo umthelela kuma-VIP receptor.
I-Exendin-4 isetshenziswe njenge-incretin mimetics yokwelapha kumaseli e-HepG2 ukuze ikhiphe umthelela wezinto ezisizayo.Iphinde yasetshenziswa njenge-agonist ye-r (GLP-1R) ukuze ikhiphe iziphazamiso ezivela ezintweni ezisizayo.
