Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide
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ʻano:
| inoa maʻamau | ʻO Exenatide | inoa Pelekane | Exenatide acetate paʻakai |
|---|---|---|---|
| Helu CAS | 141758-74-9 |
| ʻAno molekala | C184H282N50O60S |
|---|---|
| Kaumaha molekula | 4186.57000 |
| Nuipa pololei | 4184.03000 |
| PSA | 1775.05000 |
| Nā kūlana mālama | Hoʻopaʻa ʻia, mālama ma -20ºC |
| Paʻa | ʻAʻohe decomposition, ʻaʻohe hopena ʻino i ʻike ʻia inā hoʻohana a mālama ʻia e like me nā kikoʻī |
Hoʻohana:
ʻO Exenatide ka lāʻau lapaʻau mua loa i loko o kahi papa hou o nā anti-diabetics i kapa ʻia ʻo ka incretin mimetics, a ua hōʻike ʻia ʻo ia ka adjunctive therapy e hoʻomaikaʻi ai i ka mana glycemic i nā poʻe maʻi me ka maʻi diabetes type 2 e lawe nei i ka metformin, kahi sulfonylurea, a i ʻole nā mea ʻelua, akā ʻaʻole i loaʻa. Loaʻa i ka mana glycemic kūpono.ʻO Exenatide kahi analog hana o ka incretin kanaka Glucagon-Like Peptide-1 (GLP-1).Hoʻokuʻu maoli ʻia ʻo GLP-1 mai nā cell i loko o ka ʻāpana GI i ka pane ʻana i ka ʻai ʻana i ka meaʻai a hana i kāna mea hoʻokipa ma nā b-cell e potentiate glucose-stimulated insulin secretion.ʻO Exenatide kahi agonist hana lōʻihi ma ka loaʻa ʻana o GLP-1.He mana synthetic ia o kahi peptide 39-amino acid i loaʻa i loko o nā huna huna o ka moʻo monster Gila. ʻO ia hoʻi e hoʻohaʻahaʻa i ka pae kiʻekiʻe o ka glucagon serum i ka wā hyperglycemic ma hope o ka ʻai ʻana, akā ʻaʻole ia e keʻakeʻa i ka hoʻokuʻu ʻana o ka glucagon i pane i ka hypoglycemia.ʻO ka regimen dosing no exenatide he 5 a i ʻole 10 mg ʻelua i kēlā me kēia lā, lawelawe ʻia ma ke ʻano he subcutaneous injection i loko o hoʻokahi hola ma mua o ka ʻaina kakahiaka a me ke ahiahi.Ma hope o ka hoʻokele subcutaneous, hiki ke kiʻekiʻe o ka exenatide plasma kiʻekiʻe i 2.1 mau hola, a ʻo ka ʻōlelo pharmacokinetic plasma e hoʻohālikelike ʻia.ʻO nā hanana ʻino maʻamau i hōʻike ʻia me ka exenatide, ʻo ia ka nausea, ka luaʻi ʻana, ka maʻi maʻi ʻeha, ka ʻehaʻeha, ka noʻonoʻo, ke poʻo, a me ka dyspepsia.
Hiki i ka Exendin-4 ke ho'āla i ka mea loaʻa GLP-1, hiki i ka mea hoʻokipa ke hoʻonui i nā pae cAMP o nā pūnaewele acinar pancreatic i loko intracellular, akā ʻaʻohe hopena i ka loaʻa VIP.
Ua hoʻohana ʻia ʻo Exendin-4 ma ke ʻano he incretin mimetics no ka mālama ʻana i nā cell HepG2 e kāpae i ka mana o nā mea kōkua.Ua hoʻohana ʻia ʻo ia ma ke ʻano he r (GLP-1R) agonist e kāpae i ke keakea mai nā mea kōkua.
