Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide
Qhagamshelana nam:
Email : salesperson66@yeah.net
whatsapp: +8619832408762
wickr: fairyqf
Skype: +8619832408762
Uphawu:
| Igama eliqhelekileyo | Exenatide | Igama lesiNgesi | Exenatide ityuwa ye-acetate |
|---|---|---|---|
| Inombolo yeCAS | 141758-74-9 |
| Ifomula yemolekyuli | I-C184H282N50O60S |
|---|---|
| Ubunzima bemolekyuli | 4186.57000 |
| Ubunzima obuchanekileyo | 4184.03000 |
| PSA | 1775.05000 |
| Iimeko zokugcina | Itywinwe, igcine kwi -20ºC |
| Uzinzo | Akukho ukubola, akukho zimpendulo eziyingozi zaziwayo ukuba zisetyenziswe kwaye zigcinwe ngokweenkcukacha |
Ukusetyenziswa:
I-Exenatide liyeza lokuqala kwiklasi entsha ye-anti-diabetics eyaziwa ngokuba yi-incretin mimetics, kwaye iboniswa njengonyango lokuncedisa ukuphucula ukulawulwa kwe-glycemic kwizigulane ezinesifo seswekile esithatha i-metformin, i-sulfonylurea, okanye zombini, kodwa uzuze ulawulo olwaneleyo lwe-glycemic.I-Exenatide yi-analog esebenzayo ye-incretin yomntu iGlucagon-Like Peptide-1 (GLP-1).I-GLP-1 ikhutshwa ngokwendalo kwiiseli kwiphecana le-GI ekuphenduleni ukutya kwaye isebenze kwi-receptor yayo kwiiseli ze-b ukwenza i-glucose-stimulated secretion ye-insulin.I-Exenatide yi-agonist esebenza ixesha elide kwi-GLP-1 receptor.Yinguqulelo eyenziweyo ye-39-amino acid peptide efunyenwe kwi-salivary secretions ye-Gila monster lizard.kwaye imodareyitha amanqanaba aphezulu e-serum glucagon ngexesha le-hyperglycemic emva kokutya, kodwa ayiphazamisi ukukhululwa kweglucagon ekuphenduleni i-hypoglycemia.Irejimeni ye-dosing ye-exenatide yi-5 okanye i-10 mg kabini imihla ngemihla, ilawulwa njenge-injection subcutaneous ngaphakathi kweyure ngaphambi kokutya kwasekuseni nakusihlwa.Ukulandela ukulawulwa kwe-subcutaneous, i-peak plasma concentrations ye-exenatide ifikelelwa kwi-2.1 h, kwaye iprofayili ye-plasma ye-pharmacokinetic i-dose ngokulinganayo.Ezona ziganeko zingathandekiyo zixhaphakileyo ezixelwe nge-exenatide ziquka isicaphucaphu, ukuhlanza, urhudo, ukuziva jittery, isiyezi, intloko ebuhlungu, kunye ne-dyspepsia.
I-Exendin-4 inokusebenzisa i-GLP-1 i-receptor, i-receptor inokunyusa amanqanaba e-cAMP yeeseli ze-pancreatic acinar kwi-intracellular, kodwa ayinayo impembelelo kwi-VIP receptor.
I-Exendin-4 isetyenziswe njenge-incretin mimetics kunyango kwiiseli ze-HepG2 ukukhuphela ngaphandle impembelelo yezinto ezincedisayo.Kwakhona isetyenziswe njenge-r (GLP-1R) i-agonist ukuba ingabandakanyi ukuphazamiseka kwizinto ezincedisayo.
