Chemical Material Anesthetics anobatsira zvinodhaka CAS 59-46-1 PROCAINE
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Basic Information
Tsanangudzo
Procaine mushonga wekutindivadza munharaunda ine para-amino basa.Sensitization inonyanya kubata basa rekurapa, mazino uye veterinary.
Chemical Properties
Iyo hydrochloride munyu ye2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 kana N2C6H4COOCH2CH2NH(C2H5)2HCl) inowanzonzi procaine.Kunyangwe iyo PABA ester isinganyungudika mumvura, iyo hydrochloride munyu inonyungudika zvakanyanya mumvura.
Uses
1.Procaine (Novocain) inonyanya kushandiswa mumazino kana maitiro ekurapa anoda infiltration anesthesia, peripheral block, kana spinal block.
2.inhibitor ye sodium channel
3. Procaine is sodium channel blocker uye inhibitor yemhando dzakasiyana-siyana.
Usage
Clinical KushandisaProcaine inokurumidza kugadzirwa muplasma necholinesterases uye muchiropa kuburikidza ne ester hydrolysis nepseudocholinesterase.Iyo in vitroelimination hafu yehupenyu inenge 60 seconds.Chero mamiriro ezvinhu anoderedza kuwanda kwecholinesterase anogona kuwedzera kuratidzwa kune procaine uye inogona kuita chepfu.Kuderera kwekuita kweenzyme kunogona kuwanikwa nekushomeka kwemajini, chiropa, kurwara, kushaya chikafu chinovaka muviri, kutadza kwerenal, kutsva, yechitatu trimester yekuzvitakura, uye nekutevera cardiopulmonary bypasssurgery.Ester hydrolysis inogadzira PABA, iyo mubatanidzwa inokonzeresa kusawirirana kunowanikwa kune theester anesthetics.Procaine haishandiswe pamusoro nekuda kwekusakwanisa kwayo kupfuura nepakati lipid membranes uye inowana kushandiswa seaninfiltration agent yekucheka kana mucous membranes, forshort maitiro.Procaine inoshandiswawo kune peripheral nerveblock uye se epidural agent yekuongorora marwadzo syndromes.