Chemical Material Anesthetics mankhwala othandizira CAS 59-46-1 PROCAINE
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Zambiri Zoyambira
Kufotokozera
Procaine ndi mankhwala am'deralo omwe ali ndi ntchito ya para-amino.Kudziwitsa anthu makamaka kumagwira ntchito zachipatala, zamano ndi zachinyama.
Chemical Properties
Mchere wa hydrochloride wa 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 kapena N2C6H4COOCH2CH2NH(C2H5)2HCl) nthawi zambiri amatchedwa procaine.Ngakhale kuti PABA ester ndi insoluble m'madzi, mchere wa hydrochloride umasungunuka kwambiri m'madzi.
Ntchito
1.Procaine (Novocain) imagwiritsidwa ntchito makamaka m'mano kapena njira zamankhwala zomwe zimafuna kulowetsa anesthesia, peripheral block, kapena spinal block.
2.inhibitor ya sodium channel
3. Procaine ndi sodium channel blocker ndi inhibitor ya njira zosiyanasiyana.
Kugwiritsa ntchito
Kugwiritsa Ntchito ZachipatalaProcaine imapangidwa mwachangu m'madzi a m'magazi ndi cholinesterase komanso m'chiwindi kudzera mu ester hydrolysis ndi pseudocholinesterase.Theka la moyo wa in vitroelimination ndi pafupifupi masekondi 60.Chikhalidwe chilichonse chomwe chimachepetsa kuchuluka kwa cholinesterase chikhoza kuwonjezera kukhudzana ndi procaine komanso kawopsedwe.Kuchepa kwa enzyme kumatha kupezeka ndi kuchepa kwa majini, matenda a chiwindi, zilonda zam'mimba, kuperewera kwa zakudya m'thupi, kulephera kwa aimpso, kuyaka, trimester yachitatu ya mimba, komanso kutsatira opaleshoni yamtima.Ester hydrolysis imapanga PABA, yomwe imayang'anira zochitika zomwe zimachitika ku theester anesthetics.Procaine simagwiritsidwa ntchito pamutu chifukwa chakulephera kudutsa mu lipid nembanemba ndipo imagwira ntchito ngati njira yolowera pakhungu kapena mucous nembanemba, njira zazifupi.Procaine imagwiritsidwanso ntchito ngati zotumphukira mitsempha yamagazi komanso ngati epidural wothandizira kuti azindikire ma syndromes opweteka.