Ọgwụ anestetiiki kemịkalụ inyeaka CAS 59-46-1 PROCAINE
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Ozi bụ isi
Nkọwa
Procaine bụ ọgwụ anestetiiki mpaghara nwere ọrụ para-amino.Mmetụta uche na-emetụtakarị ọrụ ahụike, eze na ọgwụgwọ anụmanụ.
Njirimara kemịkalụ
Nnu hydrochloride nke 2- (diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 ma ọ bụ N2C6H4COOCH2CH2NH(C2H5)2HCl) ka a na-akpọkarị procaine.Ọ bụ ezie na PABA ester bụ ihe a na-adịghị ahụkebe na mmiri, nnu hydrochloride na-agbaze na mmiri.
Na-eji
1.Procaine (Novocain) na-ejikarị na eze ma ọ bụ usoro ahụike na-achọ infiltration anesthesia, mpụta ngọngọ, ma ọ bụ ọkpụkpụ azụ.
2.onye na-egbochi ọwa sodium
3. Procaine bụ onye na-egbochi ọwa sodium na mgbochi nke usoro dị iche iche.
Ojiji
Iji ụlọ ọgwụProcaine na-eme ngwa ngwa metabolized na plasma site na cholinesterases na imeju site na ester hydrolysis site pseudocholinesterase.Ọkara ndụ in vitroelimination bụ ihe dịka 60 sekọnd.Ọnọdụ ọ bụla nke na-ebelata mkpokọta cholinesterase nwere ike ịbawanye ohere nke procaine na nsi nwere ike ime.Enwere ike ịchọta ọrụ Decreasedenzyme na ụkọ mkpụrụ ndụ ihe nketa, ọrịa imeju, ọrịa ọjọọ, erighị ihe na-edozi ahụ, ọdịda akụrụ, ọkụ, n'ime afọ atọ nke afọ ime, na-esochi ịwa ahụ nke obi.Ester hydrolysis na-emepụta PABA, nke na-ahụ maka mmeghachi ahụ nfụkasị ahụ na-emekarị na anestetiiki theester.A naghị eji procaine eme ihe n'elu n'ihi na ọ nwere ike ịgafe n'ime akpụkpọ anụ lipid wee chọpụta na a na-eji ya dị ka ihe na-ekpo ọkụ maka akpụkpọ anụ ma ọ bụ akpụkpọ anụ mucous, usoro dị mkpirikpi.A na-ejikwa procaine maka mgbochi akwara dị n'akụkụ yana dịka onye na-ahụ maka epidural iji chọpụta ọrịa mgbu.