Cov khoom siv tshuaj loog siv tshuaj loog CAS 59-46-1 PROCAINE
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Cov ntaub ntawv yooj yim
Kev piav qhia
Procaine yog ib qho tshuaj loog hauv zos nrog rau kev ua haujlwm para-amino.Kev hnov mob feem ntau cuam tshuam txog kev kho mob, kho hniav thiab kws kho tsiaj.
Chemical Properties
Hydrochloride ntsev ntawm 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 los yog N2C6H4COOCH2CH2NH (C2H5) 2HCl) feem ntau hu ua procaine.Txawm hais tias PABA ester yog insoluble hauv dej, hydrochloride ntsev yog soluble hauv dej.
Siv
1.Procaine (Novocain) feem ntau yog siv rau hauv kev kho hniav lossis kev kho mob uas yuav tsum tau siv tshuaj loog infiltration, peripheral block, lossis txha caj qaum.
2.inhibitor ntawm sodium channel
3. Procaine yog sodium channel blocker thiab inhibitor ntawm ntau yam txheej txheem.
Kev siv
Kev siv tshuaj kho mobProcaine yog metabolized sai heev hauv cov ntshav los ntawm cholinesterases thiab hauv daim siab ntawm ester hydrolysis los ntawm pseudocholinesterase.Nyob rau hauv vitroelimation ib nrab-lub neej yog kwv yees li 60 vib nas this.Txhua yam mob uas txo cov cholinesterase concentration tuaj yeem ua rau muaj kev cuam tshuam rau procaine thiab muaj peev xwm toxicity.Kev ua haujlwm tsis muaj zog tuaj yeem pom nrog cov caj ces tsis muaj peev xwm, kab mob siab, mob qog noj ntshav, tsis muaj zaub mov, lub raum tsis ua haujlwm, kub hnyiab, peb lub hlis twg ntawm cev xeeb tub, thiab tom qab kev phais mob plawv.Ester hydrolysis tsim PABA, lub luag haujlwm rau kev ua xua rau cov tshuaj loog.Procaine tsis siv tshuaj pleev ib ce vim tias nws tsis muaj peev xwm dhau los ntawm lipid daim nyias nyias thiab pom siv los ua cov tshuaj tua kab mob rau daim tawv nqaij los yog mucous daim nyias nyias, cov txheej txheem luv luv.Procaine kuj tseem siv rau peripheral nerveblock thiab ua tus neeg sawv cev epidural los kuaj mob mob.