Mea Kemika Anesthetics nā lāʻau kōkua CAS 59-46-1 PROCAINE
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ʻIke Kumu
wehewehe
ʻO ka Procaine kahi lāʻau lapaʻau kūloko me kahi hana para-amino.Hoʻopili nui ka Sensitization i nā ʻoihana lapaʻau, niho a me nā holoholona.
Na Waiwai Kemika
ʻO ka paʻakai hydrochloride o 2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 a i ʻole N2C6H4COOCH2CH2NH(C2H5)2HCl) i kapa ʻia he procaine.ʻOiai ʻaʻole hiki ke hoʻoheheʻe ʻia ka ester PABA i ka wai, hiki ke hoʻoheheʻe ʻia ka paʻakai hydrochloride i ka wai.
Hoʻohana
1. Hoʻohana nui ʻia ʻo Procaine (Novocain) i nā kaʻina niho a i ʻole nā mea lapaʻau e koi ana i ka infiltration anesthesia, peripheral block, a i ʻole spinal block.
2.inhibitor o ka sodium channel
3. ʻO ka Procaine he mea hoʻopaʻa i ka channel sodium a me ka mea pale o nā ʻano hana like ʻole.
Hoʻohana
Hoʻohana lāʻau lapaʻauHoʻopili koke ʻia ka Procaine i loko o ka plasma e nā cholinesterases a i loko o ke ake ma o ka ester hydrolysis e kahi pseudocholinesterase.ʻO ka hapalua o ke ola in vitroelimination ma kahi o 60 kekona.ʻO kēlā me kēia kūlana e hoʻemi ana i ka neʻe ʻana o ka cholinesterase hiki ke hoʻonui i ka ʻike i ka procaine a me nā mea ʻona.Hiki ke loaʻa ka hana decreasedenzyme me ka hemahema genetic, liverdisease, malignancy, malnutrition, renal failure, kuni, kolu trimester o ka hāpai ʻana, a ma hope o ka cardiopulmonary bypass surgery.Hoʻopuka ka Ester hydrolysis i ka PABA, ka mea hoʻohui e pili ana i nā hopena maʻi maʻamau i ka anesthetics theester.ʻAʻole hoʻohana ʻia ʻo Procaine ma muli o kona hiki ʻole ke hele i loko o nā membrane lipid a loaʻa iā ia ka hoʻohana ʻana ma ke ʻano he aninfiltration agent no ka ʻili a me ka mucous membranes, no nā kaʻina hana pōkole.Hoʻohana pū ʻia ʻo Procaine no ka nerveblock peripheral a ma ke ʻano he epidural agent e ʻike ai i nā maʻi ʻeha.