I-Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin HUMAN, OVINE POCINE RAT MOUSE 2ACOH 6H2O

I-Somatostatin, eyaziwa nangokuthi i-hormone yokukhula ye-hormone suppressor (GHIH) noma amanye amagama ambalwa, iyi-hormone ye-peptide elawula uhlelo lwe-endocrine futhi ithinta ukuhanjiswa kwe-neurotransmission kanye nokwanda kwamangqamuzana ngokusebenzisana nama-G-protein-coupled somatostatin receptors futhi ivimbele ukukhululwa kwezinhlobonhlobo ze amahomoni.Amahomoni esibili.I-Somatostatin ivimbela ukukhiqizwa kwe-insulin ne-glucagon.

I-Somatostatin iza ngezinhlobo ezimbili ezisebenzayo, ezikhiqizwa ukusikwa ngokushintshana kwe-progenin eyodwa: eyodwa equkethe ama-amino acid ayi-14 (eboniswe ebhokisini lolwazi kwesokudla), kanti enye inama-amino acid angama-28.

Ezilwaneni ezinomgogodla, kunezinhlobo eziyisithupha ze-somatostatin zofuzo, eziqanjwe i-SS1, SS2, SS3, SS4, SS5, kanye ne-SS6.I-Zebrafish inazo zonke eziyisithupha.Izakhi zofuzo eziyisithupha ezihlukene, kanye nama-somatostatin receptors amahlanu ahlukene, anikeza i-somatostatin inhlobonhlobo yemisebenzi.Abantu banofuzo olulodwa kuphela lwe-somatostatin, i-SST.

uhlelo lokugaya ukudla
I-Somatostatin ikhiqizwa amaseli e-delta ezindaweni eziningi ohlelweni lokugaya ukudla, okuyi-pyloric sinuses, duodenum, kanye neziqhingi.

I-Somatostatin ekhishwe yizono ze-pyloric ingena enhliziyweni ngokusebenzisa uhlelo lwe-portal bese ingena ekujikelezeni kwesistimu endaweni yokuvimbela.Ngaphezu kwalokho, i-somatostatin ekhishwe amaseli e-δ ingasebenza ngendlela ye-paracrine.

Esiswini, i-somatostatin isebenza ngokuqondile kumaseli e-parietal akhiqiza i-asidi ngokusebenzisa i-G-protein-coupled receptors (evimbela i-adenylate cyclase futhi ngaleyo ndlela iphikisane ngempumelelo nokukhuthazwa kwe-histamine) ukuze kuncishiswe ukukhishwa kwe-asidi esiswini.I-Somatostatin iphinde ibambezele ngempumelelo inqubo yokugaya ngokunciphisa ngokungaqondile ukukhiqizwa kwe-asidi yesisu ngokuvimbela ukukhululwa kwamanye amahomoni afana ne-gastrin ne-histamine.