Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin MOTHO, OVINE PORCINE RAT MOUSE 2ACOH 6H2O

Somatostatin, e tsejoang hape e le kholo ea hormone suppressor hormone (GHIH) kapa mabitso a mang a mangata, ke hormone ea peptide e laolang tsamaiso ea endocrine 'me e ama methapo ea methapo le ho ata ha lisele ka ho sebelisana le G-protein-coupled somatostatin receptors le ho thibela ho lokolloa ha mefuta e sa tšoaneng. lihomone.Li-hormone tsa bobeli.Somatostatin e thibela tlhahiso ea insulin le glucagon.

Somatostatin e tla ka mefuta e 'meli e sebetsang, e hlahisoang ke ho khaola ha progenin e le' ngoe: e 'ngoe e na le 14 amino acid (e bontšitsoeng lebokoseng la boitsebiso ka ho le letona), 'me e' ngoe e na le 28 amino acid.

Liphoofolo tse nang le lesapo la mokokotlo, ho na le liphatsa tsa lefutso tse tšeletseng tse fapaneng tsa somatostatin, tse bitsoang SS1, SS2, SS3, SS4, SS5, le SS6.Zebrafish li na le tse tšeletseng kaofela.Liphatsa tsa lefutso tse tšeletseng tse fapaneng, hammoho le li-receptor tse hlano tse fapaneng tsa somatostatin, li fa somatostatin mesebetsi e mengata e fapaneng.Batho ba na le lefutso le le leng feela la somatostatin, SST.

tsamaiso ea tshilong ya dijo
Somatostatin e hlahisoa ke lisele tsa delta libakeng tse ngata tsamaisong ea tšilo ea lijo, e leng pyloric sinuses, duodenum le islets.

Somatostatin e lokolloa ke libe tsa pyloric e kena pelong ka tsamaiso ea li-portal ebe e kena tsamaisong ea tsamaiso ho ea sebakeng sa thibelo.Ntle le moo, somatostatin e lokollotsoeng ke lisele tsa δ e ka sebetsa ka mokhoa oa paracrine.

Ka mpeng, somatostatin e sebetsa ka ho toba liseleng tsa parietal tse hlahisang asiti ka li-receptor tsa G-protein-coupled (tse thibelang adenylate cyclase 'me kahoo li hanyetsana le ho tsosoa ha histamine) ho fokotsa secretion ea gastric acid.Somatostatin e boetse e liehisa ts'ebetso ea tšilo ea lijo ka mokhoa o sa tobang ka ho fokotsa tlhahiso ea asiti ea mala ka ho thibela ho lokolloa ha lihomone tse ling tse kang gastrin le histamine.