Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin HUMAN, OVINE PORCINE RAT MOUSE 2ACOH 6H2O

Somatostatin, nke a makwaara dị ka hormone suppressor hormone (GHIH) ma ọ bụ ọtụtụ aha ndị ọzọ, bụ hormone peptide nke na-achịkwa usoro endocrine ma na-emetụta neurotransmission na mmụba cell site na iso G-protein-coupled somatostatin receptors na igbochi ntọhapụ nke ụdị dị iche iche. homonụ.Hormones nke abụọ.Somatostatin na-egbochi mmepụta insulin na glucagon.

Somatostatin na-abịa n'ụdị abụọ na-arụ ọrụ, nke a na-emepụta site na nbibi nke otu progenin: otu nke nwere amino acid 14 (gosipụtara n'igbe ozi dị n'aka nri), na nke ọzọ nwere amino acid 28.

Na vertebrates, e nwere isii dị iche iche somatostatin genes, aha ya bụ SS1, SS2, SS3, SS4, SS5, na SS6.Zebrafish nwere ha isii.Mkpụrụ ndụ ihe nketa isii, yana ndị na-anabata somatostatin ise dị iche iche, na-enye somatostatin ọtụtụ ọrụ dị iche iche.Ụmụ mmadụ nwere naanị otu mkpụrụ ndụ somatostatin, SST.

usoro mgbari nri
A na-ezobe Somatostatin site na mkpụrụ ndụ delta n'ọtụtụ ebe na sistem nri nri, ya bụ pyloric sinuses, duodenum, na agwaetiti.

Somatostatin wepụtara site na sinuses pyloric na-abanye n'ime obi site na sistemu portal wee banye na mgbasa ozi sistemu na saịtị mgbochi.Na mgbakwunye, somatostatin wepụtara site na mkpụrụ ndụ δ nwere ike ịrụ ọrụ n'ụzọ paracrine.

N'ime afọ, somatostatin na-arụ ọrụ ozugbo na mkpụrụ ndụ parietal na-emepụta acid site na G-protein-coupled receptors (nke na-egbochi adenylate cyclase ma si otú a na-emegide mkpali histamine nke ọma) iji belata secretion acid gastric.Somatostatin na-ebelatakwa usoro mgbari nri nke ọma site n'ibelata mmepụta acid afọ na-apụtaghị ìhè site na igbochi mwepụta nke homonụ ndị ọzọ dị ka gastrin na histamine.