Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin MUNTHU, OVINE PORCINE RAT MOUSE 2ACOH 6H2O

Somatostatin, yomwe imadziwikanso kuti kukula kwa hormone suppressor hormone (GHIH) kapena mayina ena angapo, ndi hormone ya peptide yomwe imayang'anira dongosolo la endocrine ndipo imakhudza kufalikira kwa ma neurotransmission ndi kufalikira kwa maselo mwa kuyanjana ndi G-protein-coupled somatostatin receptors ndikuletsa kutulutsidwa kwa mitundu yosiyanasiyana. mahomoni.Mahomoni achiwiri.Somatostatin imalepheretsa kupanga kwa insulin ndi glucagon.

Somatostatin imabwera m'mitundu iwiri yogwira ntchito, yopangidwa ndi kudula mosinthana kwa progenin imodzi: imodzi yokhala ndi ma amino acid 14 (yowonetsedwa mubokosi lazambiri kumanja), ndipo ina imakhala ndi ma amino acid 28.

Mu vertebrates, pali mitundu isanu ndi umodzi ya somatostatin, yotchedwa SS1, SS2, SS3, SS4, SS5, ndi SS6.Zebrafish ili ndi zonse zisanu ndi chimodzi.Mitundu isanu ndi umodzi yosiyana, pamodzi ndi ma receptor asanu osiyanasiyana a somatostatin, amapatsa somatostatin ntchito zosiyanasiyana.Anthu ali ndi jini imodzi yokha ya somatostatin, SST.

kugaya chakudya
Somatostatin imatulutsidwa ndi ma cell a delta m'malo osiyanasiyana m'mimba, monga pyloric sinuses, duodenum, ndi islets.

Somatostatin anamasulidwa ndi pyloric sinuses amalowa mu mtima kudzera zipata dongosolo ndiyeno kulowa zokhudza zonse kufalitsidwa kwa malo chopinga.Kuphatikiza apo, somatostatin yotulutsidwa ndi maselo a δ imatha kugwira ntchito mwanjira ya paracrine.

M'mimba, somatostatin imagwira ntchito mwachindunji pama cell a parietal omwe amapanga asidi kudzera mu ma G-protein-coupled receptors (omwe amaletsa adenylate cyclase ndipo motero amatsutsana ndi kukondoweza kwa histamine) kuti achepetse kutulutsa kwa asidi m'mimba.Somatostatin imachepetsanso m'mimba mwa njira ina yochepetsera kupanga kwa asidi m'mimba mwa kutsekereza kutulutsa kwa mahomoni ena monga gastrin ndi histamine.