Ubonelelo ngoMveliso 99% Ucoceko olumhlophe lwePowder ye-Antitumor Polypeptide Pharma Uphando loMhlaza weBanga leMELITTIN CAS 20449-79-0

I-MELITTIN CAS 20449-79-0 Ukusetyenziswa:

I-Melitin yeyona nto isebenzayo yetyhefu yenyosi.I-Beevenom luhlobo lwetyhefu ecacileyo enevumba elimnandi elivezwa ngamadlala etyhefu yenyosi yabasebenzi kunye namadlala ancedisayo.Xa iphulwa, iyakhutshwa kwi-stinger.Phakathi kwezinto ezininzi ze-bee venom, i-melittin inomxholo ophezulu, i-akhawunti malunga ne-50% yesisindo esomileyo se-bee venom, kwaye inomsebenzi ophezulu we-biological.I-Melittin yi-peptide yomgca eyenziwe ngama-amino acids angama-26, kunye nobunzima be-molecular 2849. I-Melittin inomsebenzi ophezulu we-biological.Izifundo zanamhlanje ze-pharmacological zibonise ukuba i-anti-inflammatory, analgesic, inhibiting platelet aggregation, i-anti-AIDS kunye nezinye iziphumo ezininzi.I-Melittin inokuvelisa isiphumo esinamandla sokubulala kwiiseli ezahlukeneyo zethumba ngeendlela ezahlukeneyo, kwaye liyeza elithembisayo lendalo elichasene nethumba.

I-Melittin inokuthintela ukukhula kunye nokuveliswa kweentlobo ezingaphezu kwama-20 ze-Gram-positive kunye ne-negative bacteria, kwaye inokuphucula ukusebenza kwe-antibacterial ye-sulfonamides kunye ne-penicillins.I-Melittin itshabalalisa i-membrane yeseli yebhakteria ngokubopha kwi-membrane ukufezekisa injongo ye-bacteriolysis.Zombini i-melittin kunye nezinto eziphuma kuyo ezintandathu zinokutshintsha umsebenzi we-T lymphocytes ezosulelwe yi-HIV, zithintele ukuphindaphinda kwe-HIV, kwaye zinciphise ukosuleleka kwentsholongwane.

1. Isiphumo sokubulala ngokuthe ngqo kwi-In vitro imifuniselo iqinisekisile ukuba i-melittin inesiphumo esicacileyo sokubulala kwiiseli ezahlukeneyo ze-tumor ezifana ne-osteosarcoma, umhlaza we-ovarian, kunye ne-glioma, kwaye umphumo wokubulala uhambelana ngokufanelekileyo kunye nedosi.I-Melittin inokubulala iiseli zethumba kwaye ithintele ukukhula kweeseli zethumba, kwaye ayinayo impembelelo ecacileyo ekukhuleni kweeseli eziqhelekileyo.I-Melittin inokufaka kwi-membrane yeseli yeeseli ze-K562, yenze ii-pores, ikhuthaze ukungena kwe-Ca2 +, ikhulise i-concentration ye-Ca2 + kwiiseli, ibangele i-cell lysis, kwaye ibulale ngokuthe ngqo iiseli ze-K562.Ngokuqhelekileyo kukholelwa ukuba i-melittin inyibilikisa inwebu ye-mitochondrial yeeseli, inqanda ukusebenza okuqhelekileyo kokuphefumla kweeseli zethumba, itshabalalisa amandla abo okuphefumla, inqanda ukukhula kwezicubu zethumba, kwaye ibulala ngokuthe ngqo iiseli zethumba.
2. Impembelelo ye-Immunomodulatory I-Cellular immunity yinto ebalulekileyo yokukhusela umzimba ngokuchasene namathumba kunye nosulelo lwentsholongwane.Ubume bomzimba we-immune immune immune idlala indima ebalulekileyo kwisehlo kunye nophuhliso lwamathumba.Ukuphucula ukusebenza kwe-immune yeselula kunokudlala umphumo othile wokulwa ne-tumor.
3. Ukungeniswa kwe-apoptosis yeseli ye-tumor, ekwabizwa ngokuba kukufa kweseli ecwangcisiweyo, yinkqubo yebhayoloji yeseli esebenzayo elawulwa ziintlobo ngeentlobo zemfuza.Ke ngoko, i-apoptosis yinkqubo esebenzayo, ebandakanya ukusebenza, ukubonakaliswa kunye nokulawulwa koluhlu lweejini.Uphononongo lwangoku lubonise ukuba uninzi lwamachiza e-chemotherapeutic anokufikelela kwiinjongo zonyango ngokufaka i-apoptosis kwiiseli zomhlaza.Nokuba ngaba ukukhuthaza i-apoptosis ibe yenye yeendlela zokujonga amayeza e-anticancer.

I-Melittin inokuthintela umsebenzi we-sPLA2 kwimithombo eyahlukeneyo, kwaye izinga lokuvimbela umsebenzi we-sPLA2 kwi-synovial fluid yezigulane ze-RA zingafikelela kwi-96%.Ngoko ke, ukusetyenziswa kwe-melittin kunokunciphisa ukuphuhliswa kwe-RA.

I-sub-dose ye-melittin inokunciphisa kakhulu izinga le-lysis lokuncedisa kwiiseli.Le ndlela yokukhusela inokuthi ihambelane ne-melittin ekhuthaza ukungena kwe-Ca2 +, ukuvuselela inkqubo ye-intracellular transduction system kunye ne-protein synthesis yokukhusela.Kucetyiswa ukuba ukusetyenziswa kwexabiso elifanelekileyo le-melittin kunexabiso elithile lekliniki kunyango lwe-RA yi-Chemicalbook.Kwiminyaka yakutshanje, uphando lubonise ukuba ukugxilwa okwahlukileyo kwe-melittin kunokuchaphazela imisebenzi yeeseli ngokusebenzisa amajelo ahlukeneyo kwaye zenze iintlobo zeziphumo zebhayoloji.Ukusetyenziswa ngokufanelekileyo kwe-melittin kuya kunika unyango olutsha kwezinye izifo.